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Tbio
SLC22A9
Solute carrier family 22 member 9

Protein Summary
Description
Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279178
  • ENSP00000279178
  • ENSG00000149742
  • ENST00000536333
  • ENSP00000440206

Symbol
  • hOAT4
  • OAT7
  • UST3
  • OAT4
  • OAT7
  • ust3
  • HOAT4
  • UST3H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
chemical
0.68
cell line
0.62
molecular function
0.6
disease
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.22   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.22   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
ELOVL2
Tbio
Novelty:  0.00665823
p_int:  0.99998992
p_ni:  0.000009896
p_wrong:  1.84e-7
Data Source:  BioPlex
TMEM242
Tdark
Novelty:  0.99055845
p_int:  0.999957528
p_ni:  0.000007832
p_wrong:  0.00003464
Score:  0.186
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.999944682
p_ni:  0.000055318
Score:  0.217
Data Source:  BioPlex,STRINGDB
TMEM115
Tbio
Novelty:  0.02097567
p_int:  0.999934471
p_ni:  0.000059038
p_wrong:  0.000006491
Score:  0.167
Data Source:  BioPlex,STRINGDB
SLC25A51
Tbio
Family:  Transporter
Novelty:  0.21568087
p_int:  0.999890148
p_ni:  0.000109846
p_wrong:  7e-9
Data Source:  BioPlex
ZDHHC21
Tbio
Family:  Enzyme
Novelty:  0.11768266
p_int:  0.999857547
p_ni:  0.000142379
p_wrong:  7.4e-8
Data Source:  BioPlex
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.999802583
p_ni:  0.000197417
Data Source:  BioPlex
SLC22A5
Tbio
Family:  Transporter
Novelty:  0.00290828
p_int:  0.999762506
p_ni:  0.000237462
p_wrong:  3.2e-8
Score:  0.305
Data Source:  BioPlex,STRINGDB
MFSD5
Tdark
Novelty:  0.58146966
p_int:  0.999500968
p_ni:  0.000499032
Data Source:  BioPlex
RAB5IF
Tdark
Novelty:  0.66468447
p_int:  0.999391603
p_ni:  0.000588036
p_wrong:  0.000020361
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
64.9
tri-iodothyronine/thyroxine ratio measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
64.9
tri-iodothyronine/thyroxine ratio measurement
1
1.8
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 9
VGNC:48951
466643
Mouse
MGI:3645714
434674
Rat
RGD:621104
192273
Opossum
solute carrier family 22 member 11-like
100013455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 9
Mouse
Rat
Opossum
solute carrier family 22 member 11-like
Publication Statistics
PubMed Score 43.22
PubMed score by year
PubTator Score 5.69
PubTator score by year
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Related Publications
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PMID
Year
Title