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Tclin
SLC22A8
Solute carrier family 22 member 8

Protein Summary
Description
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336232
  • ENSP00000337335
  • ENSG00000149452
  • ENST00000430500
  • ENSP00000398548
  • ENST00000535878
  • ENSP00000443368
  • ENST00000545207
  • ENSP00000441658

Symbol
  • OAT3
  • OAT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
chemical
0.92
molecular function
0.76
cell type or tissue
0.7
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.59   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.59   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (63)
SLC22A7
Tbio
Family:  Transporter
Novelty:  0.00964024
Score:  0.859
Data Source:  STRINGDB
SLCO1B1
Tchem
Family:  Transporter
Novelty:  0.00126613
Score:  0.799
Data Source:  STRINGDB
SLCO1B3
Tchem
Family:  Transporter
Novelty:  0.0031518
Score:  0.797
Data Source:  STRINGDB
ABCC4
Tchem
Family:  Transporter
Novelty:  0.00208051
Score:  0.795
Data Source:  STRINGDB
ABCA8
Tbio
Family:  Transporter
Novelty:  0.0698037
Score:  0.792
Data Source:  STRINGDB
ABCG2
Tchem
Family:  Transporter
Novelty:  0.00029779
Score:  0.773
Data Source:  STRINGDB
SLC47A1
Tchem
Family:  Transporter
Novelty:  0.00535064
Score:  0.746
Data Source:  STRINGDB
SLCO1A2
Tchem
Family:  Transporter
Novelty:  0.00248357
Score:  0.744
Data Source:  STRINGDB
SLC47A2
Tchem
Family:  Transporter
Novelty:  0.01171254
Score:  0.74
Data Source:  STRINGDB
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
Score:  0.736
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Organic anion transport (R-HSA-561048)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Organic anion transport
Reactome
Organic cation/anion/zwitterion transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Organic anion transport
Organic cation/anion/zwitterion transport
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
2
54.4
insomnia measurement
1
2
0
1
42.2
testosterone measurement
1
1
1
24.3
BMI-adjusted waist-hip ratio
1
1
1
7.7
waist-hip ratio
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
54.4
insomnia measurement
0
1
42.2
testosterone measurement
1
24.3
BMI-adjusted waist-hip ratio
1
7.7
waist-hip ratio
1
6.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 8
VGNC:7751
451274
Macaque
solute carrier family 22 member 8
718363
Mouse
MGI:1336187
19879
Rat
RGD:632286
83500
Dog
solute carrier family 22 member 8
VGNC:46281
476049
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 8
Macaque
solute carrier family 22 member 8
Mouse
Rat
Dog
solute carrier family 22 member 8
Publication Statistics
PubMed Score 366.59
PubMed score by year
PubTator Score 143.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title