Tbio SLC22A23 Solute carrier family 22 member 23

Protein Summary

Description

SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• A1A5C7
• A1A5C8
• Q5T8B8
• Q6ZMH3
• Q8IW73

Gene Name

• SLC22A23

Ensembl ID

• ENST00000380298
• ENSP00000369653
• ENSG00000137266
• ENST00000380302
• ENSP00000369657
• ENST00000406686
• ENSP00000385028
• ENST00000490273
• ENSP00000419463

Symbol

• C6orf85
• C6orf85

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.86
phenotype	0.78
tissue sample	0.76
PubMedID	0.71
transcription factor perturbation	0.68

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc22 Family Of Organic Cation And Anion Transporters / Orphan Or Poorly Characterized Slc22 Family Members / Solute Carrier Family 22 Member 23

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (5)

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

Go To Tool

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

CLEC2D

Tbio

Novelty:  0.02501194

p_int:  0.999943606

p_ni:  0.000056394

p_wrong:  1e-9

Data Source:  BioPlex

TNFRSF10C

Tbio

Novelty:  0.0088942

p_int:  0.999865161

p_ni:  0.000020483

p_wrong:  0.000114356

Data Source:  BioPlex

ATP6V0D1

Tbio

Family:  Enzyme

Novelty:  0.05146108

p_int:  0.999703064

p_ni:  0.000296936

Data Source:  BioPlex

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.99969304

p_ni:  0.000306944

p_wrong:  1.5e-8

Data Source:  BioPlex

BMP4

Tchem

Novelty:  0.00047387

p_int:  0.999521467

p_ni:  0.000458655

p_wrong:  0.000019878

Score:  0.188

Data Source:  BioPlex,STRINGDB

LRRC55

Tbio

Family:  IC

Novelty:  0.25121277

p_int:  0.99922526

p_ni:  0.00067839

p_wrong:  0.00009635

Data Source:  BioPlex

DLK2

Tbio

Novelty:  0.06366405

p_int:  0.995442486

p_ni:  0.003627429

p_wrong:  0.000930085

Data Source:  BioPlex

SIRT2

Tchem

Family:  Epigenetic

Novelty:  0.00093962

p_int:  0.994113197

p_ni:  0.005870372

p_wrong:  0.000016431

Score:  0.183

Data Source:  BioPlex,STRINGDB

PAXBP1

Tbio

Novelty:  0.13631396

p_int:  0.985932857

p_ni:  0.014067084

p_wrong:  5.9e-8

Score:  0.167

Data Source:  BioPlex,STRINGDB

KPRP

Tdark

Novelty:  0.11744927

p_int:  0.979173145

p_ni:  0.0208079

p_wrong:  0.000018955

Score:  0.175

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
transmembrane transporter activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	5	5		96
red blood cell distribution width	EFO_0005192	3	6	6		92.9
self reported educational attainment	EFO_0004784	2	2	1	6	67.8
intelligence	EFO_0004337	4	3	1	6	67.1
household income	EFO_0009695	1	2	2		60.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	5		96
red blood cell distribution width	EFO_0005192	6		92.9
self reported educational attainment	EFO_0004784	1	6	67.8
intelligence	EFO_0004337	1	6	67.1
household income	EFO_0009695	2		60.8

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Glycoprotein
Ion transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport

GWAS Trait Find Similar Targets

No Header	No Header
cognitive function measurement
Crohn's disease
electrocardiography
household income
intelligence
mathematical ability
mean platelet volume
red blood cell distribution width
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 22 member 23	VGNC:11285	744613
Mouse	solute carrier family 22, member 23	MGI:1920352	73102
Rat	solute carrier family 22, member 23	RGD:620302	64559
Horse	solute carrier family 22 member 23	VGNC:23075	100058363
Pig	solute carrier family 22 member 23		100152838

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 22 member 23
Mouse	solute carrier family 22, member 23
Rat	solute carrier family 22, member 23
Horse	solute carrier family 22 member 23
Pig	solute carrier family 22 member 23

Publication Statistics

PubMed Score 4.98

PubMed score by year

Reset Zoom

PubTator Score 4.84

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (18)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title