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Tbio
SLC22A18
Solute carrier family 22 member 18

Protein Summary
Description
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312221
  • ENSP00000311139
  • ENSG00000110628
  • ENST00000347936
  • ENSP00000307859
  • ENST00000380574
  • ENSP00000369948
  • ENST00000649076
  • ENSP00000497561

Symbol
  • BWR1A
  • BWSCR1A
  • HET
  • IMPT1
  • ITM
  • ORCTL2
  • SLC22A1L
  • TSSC5
  • HET
  • ITM
  • BWR1A
  • IMPT1
  • TSSC5
  • ORCTL2
  • BWSCR1A
  • SLC22A1L
  • p45-BWR1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
tissue sample
0.63
virus perturbation
0.59
gene perturbation
0.56
PubMedID
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.88   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.88   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.990239862
p_ni:  0.009760125
p_wrong:  1.4e-8
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.988533206
p_ni:  0.011466783
p_wrong:  1.1e-8
Data Source:  BioPlex
CA14
Tclin
Family:  Enzyme
Novelty:  0.00864764
p_int:  0.977137425
p_ni:  0.02286256
p_wrong:  1.5e-8
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.923183535
p_ni:  0.07679723
p_wrong:  0.000019236
Score:  0.163
Data Source:  BioPlex,STRINGDB
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.916553701
p_ni:  0.083446182
p_wrong:  1.17e-7
Data Source:  BioPlex
GYPA
Tbio
Novelty:  0.00067203
p_int:  0.914290946
p_ni:  0.085708986
p_wrong:  6.8e-8
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.913889016
p_ni:  0.085973932
p_wrong:  0.000137051
Score:  0.193
Data Source:  BioPlex,STRINGDB
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.909446022
p_ni:  0.090461898
p_wrong:  0.00009208
Data Source:  BioPlex
AMIGO3
Tdark
Novelty:  7.6744186
p_int:  0.89633032
p_ni:  0.1036246
p_wrong:  0.000045079
Data Source:  BioPlex
NRG1
Tbio
Novelty:  0.00095246
p_int:  0.894001084
p_ni:  0.10582182
p_wrong:  0.000177097
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) (R-HSA-5619066)

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Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Organic cation transport
Reactome
Organic cation/anion/zwitterion transport
Name
Explore in Pharos
Explore in Source
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
Disease
Disorders of transmembrane transporters
Organic cation transport
Organic cation/anion/zwitterion transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
22
8
6
1.3
99.6
HbA1c measurement
3
4
4
95.8
body mass index
3
3
4
94.3
bilirubin measurement
3
2
5
92
glucose measurement
3
3
3
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
1.3
99.6
HbA1c measurement
4
95.8
body mass index
4
94.3
bilirubin measurement
5
92
glucose measurement
3
91.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 18
VGNC:11658
450959
Mouse
MGI:1336884
18400
Rat
RGD:1303323
309131
Dog
solute carrier family 22 member 18
VGNC:52047
475997
Horse
solute carrier family 22 member 18
VGNC:23073
100060198
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 18
Mouse
Rat
Dog
solute carrier family 22 member 18
Horse
solute carrier family 22 member 18
Publication Statistics
PubMed Score 59.88
PubMed score by year
PubTator Score 29.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title