Tbio SLC22A18 Solute carrier family 22 member 18

Protein Summary

Description

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• Q96BI1
• O14906
• O43562
• O60485
• O60680
• Q7LDS5
• Q7LGF7

Gene Name

• SLC22A18

Ensembl ID

• ENST00000312221
• ENSP00000311139
• ENSG00000110628
• ENST00000347936
• ENSP00000307859
• ENST00000380574
• ENSP00000369948
• ENST00000649076
• ENSP00000497561

Symbol

• BWR1A
• BWSCR1A
• HET
• IMPT1
• ITM
• ORCTL2
• SLC22A1L
• TSSC5
• HET
• ITM
• BWR1A
• IMPT1
• TSSC5
• ORCTL2
• BWSCR1A
• SLC22A1L
• p45-BWR1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
tissue sample	0.63
virus perturbation	0.59
gene perturbation	0.56
PubMedID	0.54

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc22 Family Of Organic Cation And Anion Transporters / Orphan Or Poorly Characterized Slc22 Family Members / Solute Carrier Family 22 Member 18

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.29   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.29   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0