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Tbio
SLC22A13
Solute carrier family 22 member 13

Protein Summary
Description
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311856
  • ENSP00000310241
  • ENSG00000172940

Symbol
  • OCTL1
  • ORCTL3
  • OAT10
  • OCTL1
  • OCTL3
  • ORCTL3
  • ORCTL-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
tissue sample
0.6
kinase perturbation
0.54
tissue
0.49
gene perturbation
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.91   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.91   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
SEMG1
Tbio
Novelty:  0.0161449
p_int:  0.999384049
p_ni:  0.000615951
Score:  0.187
Data Source:  BioPlex,STRINGDB
SEMG2
Tbio
Novelty:  0.06325799
p_int:  0.999216562
p_ni:  0.00078343
p_wrong:  8e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
CCPG1
Tbio
Novelty:  0.07685013
p_int:  0.992029594
p_ni:  0.007970406
Score:  0.209
Data Source:  BioPlex,STRINGDB
XYLB
Tbio
Family:  Kinase
Novelty:  0.00540687
Score:  0.911
Data Source:  STRINGDB
OXSR1
Tbio
Family:  Kinase
Novelty:  0.11142923
Score:  0.806
Data Source:  STRINGDB
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
Score:  0.745
Data Source:  STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
Score:  0.743
Data Source:  STRINGDB
SLC17A3
Tbio
Family:  Transporter
Novelty:  0.04671795
Score:  0.725
Data Source:  STRINGDB
FUCA2
Tchem
Family:  Enzyme
Novelty:  0.02259158
Score:  0.676
Data Source:  STRINGDB
SLC19A1
Tchem
Family:  Transporter
Novelty:  0.00536763
Score:  0.674
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
71.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
71.3
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 22 member 13
696240
Mouse
MGI:2143107
102570
Rat
RGD:1583222
685081
Dog
solute carrier family 22 member 13
VGNC:46274
485587
Horse
solute carrier family 22 member 13
VGNC:23070
100053841
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 22 member 13
Mouse
Rat
Dog
solute carrier family 22 member 13
Horse
solute carrier family 22 member 13
Publication Statistics
PubMed Score 17.91
PubMed score by year
PubTator Score 6.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title