SLC22A13
Solute carrier family 22 member 13
Protein Summary
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]
- ENST00000311856
- ENSP00000310241
- ENSG00000172940
- OCTL1
- ORCTL3
- OAT10
- OCTL1
- OCTL3
- ORCTL3
- ORCTL-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.79 | ||
tissue sample | 0.6 | ||
kinase perturbation | 0.54 | ||
tissue | 0.49 | ||
gene perturbation | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.91 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 72 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.91 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 72 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (47)
SEMG1
Novelty: 0.0161449
p_int: 0.999384049
p_ni: 0.000615951
Score: 0.187
Data Source: BioPlex,STRINGDB
SEMG2
Novelty: 0.06325799
p_int: 0.999216562
p_ni: 0.00078343
p_wrong: 8e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
CCPG1
Novelty: 0.07685013
p_int: 0.992029594
p_ni: 0.007970406
Score: 0.209
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Reactome | Nicotinamide salvaging | ||||
Reactome | Nicotinate metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Nicotinamide salvaging | ||||
Nicotinate metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
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1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 1 | 2 | 71.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 71.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | solute carrier family 22 member 13 | 696240 | ||||||
Mouse | MGI:2143107 | 102570 | ||||||
Rat | RGD:1583222 | 685081 | ||||||
Dog | solute carrier family 22 member 13 | VGNC:46274 | 485587 | |||||
Horse | solute carrier family 22 member 13 | VGNC:23070 | 100053841 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | solute carrier family 22 member 13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 22 member 13 | |||||
Horse | solute carrier family 22 member 13 | |||||
Publication Statistics
PubMed Score 17.91
PubMed score by year
PubTator Score 6.74
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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