You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC20A1
Sodium-dependent phosphate transporter 1

Protein Summary
Description
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukem ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272542
  • ENSP00000272542
  • ENSG00000144136

Symbol
  • GLVR1
  • PIT1
  • PIT1
  • GLVR1
  • PiT-1
  • Glvr-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
disease perturbation
0.93
molecular function
0.88
PubMedID
0.86
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.22   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.22   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
MPP6
Tbio
Novelty:  0.08883057
p_int:  0.999900066
p_ni:  0.000099934
Score:  0.795
Data Source:  BioPlex,STRINGDB
MPP2
Tbio
Novelty:  0.0372293
p_int:  0.999830263
p_ni:  0.000169737
Score:  0.719
Data Source:  BioPlex,STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
p_int:  0.99956665
p_ni:  0.000373153
p_wrong:  0.000060197
Score:  0.444
Data Source:  BioPlex,STRINGDB
FLVCR1
Tbio
Novelty:  0.02110276
p_int:  0.999225957
p_ni:  0.000774043
Score:  0.357
Data Source:  BioPlex,STRINGDB
SLC20A2
Tbio
Family:  Transporter
Novelty:  0.00387767
p_int:  0.996544089
p_ni:  0.003446654
p_wrong:  0.000009256
Score:  0.219
Data Source:  BioPlex,STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.993779941
p_ni:  0.006220042
p_wrong:  1.7e-8
Data Source:  BioPlex
MFAP3
Tdark
Novelty:  0.55512255
p_int:  0.991299955
p_ni:  0.008700045
Data Source:  BioPlex
LIN7A
Tbio
Novelty:  0.0202389
p_int:  0.990128406
p_ni:  0.009871594
Score:  0.795
Data Source:  BioPlex,STRINGDB
LRP10
Tbio
Novelty:  0.04049684
p_int:  0.961562132
p_ni:  0.038437865
p_wrong:  3e-9
Score:  0.155
Data Source:  BioPlex,STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.958635745
p_ni:  0.041351047
p_wrong:  0.000013208
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium-coupled phosphate cotransporters
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium-coupled phosphate cotransporters
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
94.5
matrix metalloproteinase 1 measurement
1
1
1
48.5
smoking behavior
1
1
1
17.8
C-reactive protein measurement
1
1
1
15.8
leukocyte count
1
1
1
11.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
94.5
matrix metalloproteinase 1 measurement
1
48.5
smoking behavior
1
17.8
C-reactive protein measurement
1
15.8
leukocyte count
1
11.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 20 member 1
VGNC:7716
459498
Macaque
solute carrier family 20 member 1
699462
Mouse
MGI:108392
20515
Rat
RGD:621079
81826
Dog
solute carrier family 20 member 1
VGNC:46268
483066
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 20 member 1
Macaque
solute carrier family 20 member 1
Mouse
Rat
Dog
solute carrier family 20 member 1
Publication Statistics
PubMed Score 91.22
PubMed score by year
PubTator Score 31.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title