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Tchem
SLC1A7
Excitatory amino acid transporter 5

Protein Summary
Description
Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371491
  • ENSP00000360546
  • ENSG00000162383
  • ENST00000371494
  • ENSP00000360549

Symbol
  • EAAT5
  • AAAT
  • EAAT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cell line
0.7
tissue
0.55
cell type or tissue
0.53
tissue sample
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.92   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.92   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (113)
SLC38A2
Tbio
Family:  Transporter
Novelty:  0.00808235
Score:  0.876
Data Source:  STRINGDB
SLC36A2
Tchem
Family:  Transporter
Novelty:  0.01345844
Score:  0.829
Data Source:  STRINGDB
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
Score:  0.828
Data Source:  STRINGDB
SLC7A5
Tchem
Family:  Transporter
Novelty:  0.00365806
Score:  0.828
Data Source:  STRINGDB
SLC6A19
Tchem
Family:  Transporter
Novelty:  0.01581031
Score:  0.817
Data Source:  STRINGDB
SLC6A20
Tbio
Family:  Transporter
Novelty:  0.01435823
Score:  0.812
Data Source:  STRINGDB
SLC6A18
Tbio
Family:  Transporter
Novelty:  0.1198606
Score:  0.81
Data Source:  STRINGDB
SLC3A1
Tbio
Family:  Transporter
Novelty:  0.003328
Score:  0.784
Data Source:  STRINGDB
SLC36A1
Tchem
Family:  Transporter
Novelty:  0.03100896
Score:  0.75
Data Source:  STRINGDB
SLC7A3
Tbio
Family:  Transporter
Novelty:  0.00779949
Score:  0.75
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Glutamate Neurotransmitter Release Cycle (R-HSA-210500)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
SLC-mediated transmembrane transport
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
SLC-mediated transmembrane transport
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
78.6
metabolite measurement
1
2
2
73.3
urinary metabolite measurement
1
1
1
42.3
body height
1
1
1
26.1
risky sexual behaviour measurement
1
1
1
17.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
78.6
metabolite measurement
2
73.3
urinary metabolite measurement
1
42.3
body height
1
26.1
risky sexual behaviour measurement
1
17.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 1 member 7
VGNC:8104
469329
Macaque
solute carrier family 1 member 7
714080
Mouse
MGI:2444087
242607
Rat
RGD:1311928
366432
Dog
solute carrier family 1 member 7
VGNC:46267
100505395
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 1 member 7
Macaque
solute carrier family 1 member 7
Mouse
Rat
Dog
solute carrier family 1 member 7
Publication Statistics
PubMed Score 1206.92
PubMed score by year
PubTator Score 17.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title