Tchem SLC1A7 Excitatory amino acid transporter 5

Protein Summary

Description

Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

Uniprot Accession IDs

• O00341
• Q5VVZ0
• Q969Z8
• Q9BW45

Gene Name

• SLC1A7

Ensembl ID

• ENST00000371491
• ENSP00000360546
• ENSG00000162383
• ENST00000371494
• ENSP00000360549

Symbol

• EAAT5
• AAAT
• EAAT5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
cell line	0.7
tissue	0.55
cell type or tissue	0.53
tissue sample	0.51

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Excitatory Amino Acid Transporter 5

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc1 Family Of Amino Acid Transporters / Glutamate Transporter Subfamily / Excitatory Amino Acid Transporter 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1312.77   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1312.77   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0