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Tbio
SLC1A4
Neutral amino acid transporter A

Protein Summary
Description
Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234256
  • ENSP00000234256
  • ENSG00000115902
  • ENST00000531327
  • ENSP00000431942

Symbol
  • ASCT1
  • SATT
  • SATT
  • ASCT1
  • SPATCCM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
1
transcription factor perturbation
0.98
kinase perturbation
0.97
virus perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.99   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.99   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.876372287
p_ni:  0.123627693
p_wrong:  2e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
GGT5
Tbio
Family:  Enzyme
Novelty:  0.00602505
p_int:  0.827067353
p_ni:  0.172932646
Score:  0.557
Data Source:  BioPlex,STRINGDB
SLC38A2
Tbio
Family:  Transporter
Novelty:  0.00808235
Score:  0.798
Data Source:  STRINGDB
SLC7A5
Tchem
Family:  Transporter
Novelty:  0.00365806
Score:  0.765
Data Source:  STRINGDB
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
Score:  0.682
Data Source:  STRINGDB
SLC38A1
Tbio
Family:  Transporter
Novelty:  0.01350134
Score:  0.678
Data Source:  STRINGDB
SLC7A8
Tbio
Family:  Transporter
Novelty:  0.03433454
Score:  0.675
Data Source:  STRINGDB
SLC7A11
Tchem
Family:  Transporter
Novelty:  0.00238054
Score:  0.656
Data Source:  STRINGDB
ERVW-1
Tbio
Novelty:  0.00038992
Score:  0.651
Data Source:  STRINGDB
SLC7A6
Tbio
Family:  Transporter
Novelty:  0.02732334
Score:  0.646
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
3
1.1
94
5
3
0
1.1
90.9
triglyceride measurement
5
4
8
89.7
testosterone measurement
3
3
3
78.4
high density lipoprotein cholesterol measurement
2
2
2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
94
0
1.1
90.9
triglyceride measurement
8
89.7
testosterone measurement
3
78.4
high density lipoprotein cholesterol measurement
2
76.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 1 member 4
VGNC:7717
459278
Macaque
solute carrier family 1 member 4
699288
Mouse
MGI:2135601
55963
Rat
RGD:735146
305540
Dog
solute carrier family 1 member 4
VGNC:46264
481391
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 1 member 4
Macaque
solute carrier family 1 member 4
Mouse
Rat
Dog
solute carrier family 1 member 4
Publication Statistics
PubMed Score 79.99
PubMed score by year
PubTator Score 38.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title