Protein Summary
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump. The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
- ENST00000311124
- ENSP00000308895
- ENSG00000173638
- ENST00000380010
- ENSP00000369347
- ENST00000485649
- ENSP00000441772
- FLOT1
- RFC1
- RFC
- CHMD
- FOLT
- IFC1
- REFC
- RFC1
- IFC-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
disease perturbation | 0.87 | ||
biological term | 0.82 | ||
virus perturbation | 0.76 | ||
disease | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 250.82 (req: < 5)
Gene RIFs: 176 (req: <= 3)
Antibodies: 110 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 250.82 (req: >= 5)
Gene RIFs: 176 (req: > 3)
Antibodies: 110 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 21
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4