Protein Summary
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump. The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
- ENST00000311124
- ENSP00000308895
- ENSG00000173638
- ENST00000380010
- ENSP00000369347
- ENST00000485649
- ENSP00000441772
- FLOT1
- RFC1
- RFC
- CHMD
- FOLT
- IFC1
- REFC
- RFC1
- IFC-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.97 | ||
disease perturbation | 0.87 | ||
biological term | 0.82 | ||
virus perturbation | 0.76 | ||
disease | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.98 (req: < 5)
Gene RIFs: 150 (req: <= 3)
Antibodies: 110 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.98 (req: >= 5)
Gene RIFs: 150 (req: > 3)
Antibodies: 110 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 21
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (21)
Protein-Protein Interactions (72)
TNFRSF10C
Novelty: 0.0088942
p_int: 0.999998016
p_ni: 3.31e-7
p_wrong: 0.000001652
Data Source: BioPlex
CD164L2
Novelty: 0.83369268
p_int: 0.998620745
p_ni: 0.000001641
p_wrong: 0.001377613
Score: 0.689
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (4)
KEGG (2)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of folate and pterines | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism | ||||
Metabolism of folate and pterines | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 2 | 1 | 3 | 78.9 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 71.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 50.6 | |||||
glomerular filtration rate | 1 | 1 | 1 | 37.6 | |||||
creatinine measurement | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
triglyceride measurement | 3 | 78.9 | |||||
apolipoprotein A 1 measurement | 2 | 71.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 50.6 | |||||
glomerular filtration rate | 1 | 37.6 | |||||
creatinine measurement | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 19 member 1 | VGNC:14680 | 474051 | |||||
Macaque | solute carrier family 19 member 1 | 721917 | ||||||
Mouse | MGI:103182 | 20509 | ||||||
Rat | RGD:3695 | 29723 | ||||||
Dog | solute carrier family 19 member 1 | VGNC:46259 | 491606 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | solute carrier family 19 member 1 | |||||
Macaque | solute carrier family 19 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 19 member 1 | |||||
Publication Statistics
PubMed Score 208.98
PubMed score by year
PubTator Score 169.53
PubTator score by year
Related Publications
Text Mined References (252)
GeneRif Annotations (150)
Items per page:
0 of 0
PMID | Year | Title |
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