Protein Summary
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump. The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
- ENST00000311124
- ENSP00000308895
- ENSG00000173638
- ENST00000380010
- ENSP00000369347
- ENST00000485649
- ENSP00000441772
- FLOT1
- RFC1
- RFC
- CHMD
- FOLT
- IFC1
- REFC
- RFC1
- IFC-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
disease perturbation | 0.87 | ||
biological term | 0.82 | ||
virus perturbation | 0.76 | ||
disease | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.98 (req: < 5)
Gene RIFs: 150 (req: <= 3)
Antibodies: 110 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.98 (req: >= 5)
Gene RIFs: 150 (req: > 3)
Antibodies: 110 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 21
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (21)
Protein-Protein Interactions (72)
TNFRSF10C
Novelty: 0.0088942
p_int: 0.999998016
p_ni: 3.31e-7
p_wrong: 0.000001652
Data Source: BioPlex
CD164L2
Novelty: 0.83369268
p_int: 0.998620745
p_ni: 0.000001641
p_wrong: 0.001377613
Score: 0.689
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (4)
KEGG (2)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of folate and pterines | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of folate and pterines | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 2 | 1 | 3 | 78.9 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 71.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 50.6 | |||||
glomerular filtration rate | 1 | 1 | 1 | 37.6 | |||||
creatinine measurement | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 3 | 78.9 | |||||
apolipoprotein A 1 measurement | 2 | 71.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 50.6 | |||||
glomerular filtration rate | 1 | 37.6 | |||||
creatinine measurement | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 19 member 1 | VGNC:14680 | 474051 | |||||
Macaque | solute carrier family 19 member 1 | 721917 | ||||||
Mouse | MGI:103182 | 20509 | ||||||
Rat | RGD:3695 | 29723 | ||||||
Dog | solute carrier family 19 member 1 | VGNC:46259 | 491606 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 19 member 1 | |||||
Macaque | solute carrier family 19 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 19 member 1 | |||||
Publication Statistics
PubMed Score 208.98
PubMed score by year
PubTator Score 169.53
PubTator score by year
Related Publications
Text Mined References (252)
GeneRif Annotations (150)
Items per page:
0 of 0
PMID | Year | Title |
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