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Tchem
SLC18A3
Vesicular acetylcholine transporter

Protein Summary
Description
Involved in acetylcholine transport into synaptic vesicles. This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374115
  • ENSP00000363229
  • ENSG00000187714

Symbol
  • VACHT
  • CMS21
  • VACHT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.69
molecular function
0.56
phenotype
0.54
cell line
0.48
PubMedID
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 726.17   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 726.17   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 167
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0