Tchem SLC18A3 Vesicular acetylcholine transporter

Protein Summary

Description

Involved in acetylcholine transport into synaptic vesicles. This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16572
• B2R7S1
• VAChT

Gene Name

• SLC18A3

Ensembl ID

• ENST00000374115
• ENSP00000363229
• ENSG00000187714

Symbol

• VACHT
• CMS21
• VACHT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.69
molecular function	0.56
phenotype	0.54
cell line	0.48
PubMedID	0.48

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc18 Family Of Vesicular Amine Transporters / Vesicular Acetylcholine Transporter

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 726.17   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 240   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 726.17   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 167

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0