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Tclin
SLC18A2
Synaptic vesicular amine transporter

Protein Summary
Description
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473). Requisite for vesicular amine storage prior to secretion via exocytosis. This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298472
  • ENSP00000298472
  • ENSG00000165646
  • ENST00000644641
  • ENSP00000496339

Symbol
  • SVMT
  • VMAT2
  • SVAT
  • SVMT
  • VAT2
  • VMAT2
  • PKDYS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.89
biological process
0.85
kinase perturbation
0.81
molecular function
0.79
chemical
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1585.04   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1585.04   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10