Tchem SLC18A1 Chromaffin granule amine transporter

Protein Summary

Description

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• P54219
• E9PDJ5
• Q9BRE4

Gene Name

• SLC18A1

Ensembl ID

• ENST00000265808
• ENSP00000265808
• ENSG00000036565
• ENST00000276373
• ENSP00000276373
• ENST00000381608
• ENSP00000371021
• ENST00000437980
• ENSP00000413361
• ENST00000440926
• ENSP00000387549
• ENST00000519026
• ENSP00000429664

Symbol

• VAT1
• VMAT1
• CGAT
• VAT1
• VMAT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
PubMedID	0.56
cell type or tissue	0.5
chemical	0.49
cellular component	0.48

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc18 Family Of Vesicular Amine Transporters / Chromaffin Granule Amine Transporter

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.06   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.06   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (5)

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

ketanserin

SLC18A1Tchem Transporter

pKi : 8.46

reserpine

SLC18A1Tchem Transporter

INHIBITOR pKi : 7.45

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

tetrabenazine

SLC18A1Tchem Transporter

pKi : 7

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

ZMPSTE24

Tbio

Family:  Enzyme

Novelty:  0.0027993

p_int:  0.999332915

p_ni:  0.000667085

Data Source:  BioPlex

EMC4

Tbio

Novelty:  0.12174476

p_int:  0.992704041

p_ni:  0.007228828

p_wrong:  0.000067131

Score:  0.158

Data Source:  BioPlex,STRINGDB

HSD17B7

Tchem

Family:  Enzyme

Novelty:  0.04295724

p_int:  0.991347054

p_ni:  0.008626681

p_wrong:  0.000026265

Data Source:  BioPlex

OTULIN

Tbio

Family:  Enzyme

Novelty:  0.04694238

p_int:  0.990370688

p_ni:  0.008834145

p_wrong:  0.000795167

Data Source:  BioPlex

GJC1

Tbio

Novelty:  0.00375192

p_int:  0.984271833

p_ni:  0.015215178

p_wrong:  0.000512989

Data Source:  BioPlex

PDK1

Tchem

Family:  Kinase

Novelty:  0.0078496

p_int:  0.982652996

p_ni:  0.017345208

p_wrong:  0.000001796

Data Source:  BioPlex

PXMP2

Tbio

Novelty:  0.24472872

p_int:  0.982531505

p_ni:  0.017444464

p_wrong:  0.000024031

Data Source:  BioPlex

DPH6

Tbio

Family:  Enzyme

Novelty:  0.15211179

p_int:  0.98059379

p_ni:  0.005752648

p_wrong:  0.013653563

Data Source:  BioPlex

FADS1

Tchem

Family:  Enzyme

Novelty:  0.00160193

p_int:  0.976420335

p_ni:  0.022329215

p_wrong:  0.001250449

Data Source:  BioPlex

ECPAS

Tbio

Novelty:  0.04004664

p_int:  0.963326342

p_ni:  0.036673658

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (16)

Reactome (4)

KEGG (7)

PathwayCommons (4)

WikiPathways (1)

Na+/Cl- dependent neurotransmitter transporters (R-HSA-442660)

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Find Similar Targets

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Na+/Cl- dependent neurotransmitter transporters	19 targets	R-HSA-442660
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Na+/Cl- dependent neurotransmitter transporters	19 targets	R-HSA-442660
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Transport of small molecules	725 targets	R-HSA-382551

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (3)

Components (6)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
monoamine transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
serotonin:sodium symporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
drug transmembrane transporter activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (17)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	11	19	36	7.8	99.7
high density lipoprotein cholesterol measurement	EFO_0004612	7	22	32	2.2	99.7
sleep duration	EFO_0005271	3	5	5		96
apolipoprotein A 1 measurement	EFO_0004614	2	7	7		94.3
red blood cell distribution width	EFO_0005192	4	2	5		86.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	36	7.8	99.7
high density lipoprotein cholesterol measurement	EFO_0004612	32	2.2	99.7
sleep duration	EFO_0005271	5		96
apolipoprotein A 1 measurement	EFO_0004614	7		94.3
red blood cell distribution width	EFO_0005192	5		86.1

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UniProt Keyword Find Similar Targets

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Alternative splicing
Cell junction
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Glycoprotein
Membrane
Neurotransmitter transport
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

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apolipoprotein A 1 measurement
apolipoprotein B measurement
blood metabolite measurement
coronary artery disease
high density lipoprotein cholesterol measurement
lipid measurement
lipoprotein measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 18 member A1	VGNC:7739	464032
Macaque	solute carrier family 18 member A1		705489
Mouse	solute carrier family 18 (vesicular monoamine), member 1	MGI:106684	110877
Rat	solute carrier family 18 member A1	RGD:3693	25693
Dog	solute carrier family 18 member A1	VGNC:46255	486138

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 18 member A1
Macaque	solute carrier family 18 member A1
Mouse	solute carrier family 18 (vesicular monoamine), member 1
Rat	solute carrier family 18 member A1
Dog	solute carrier family 18 member A1

Publication Statistics

PubMed Score 87.06

PubMed score by year

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PubTator Score 61.98

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (21)

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PMID	Year	Title