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Tchem
SLC17A9
Solute carrier family 17 member 9

Protein Summary
Description
Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. This gene encodes a member of a family of transmembrane proteins that are involved in the transport of small molecules. The encoded protein participates in the vesicular uptake, storage, and secretion of adenoside triphosphate (ATP) and other nucleotides. A mutation in this gene was found in individuals with autosomal dominant disseminated superficial actinic porokeratosis-8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370349
  • ENSP00000359374
  • ENSG00000101194
  • ENST00000370351
  • ENSP00000359376

Symbol
  • C20orf59
  • VNUT
  • POROK8
  • C20orf59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.66
cell type or tissue
0.6
PubMedID
0.6
gene perturbation
0.55
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.69   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.69   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
SLC37A2
Tbio
Family:  Transporter
Novelty:  0.08172762
Score:  0.675
Data Source:  STRINGDB
ABCG4
Tbio
Family:  Transporter
Novelty:  0.02628545
Score:  0.557
Data Source:  STRINGDB
PANX1
Tbio
Family:  IC
Novelty:  0.00159814
Score:  0.555
Data Source:  STRINGDB
SLC37A1
Tbio
Family:  Transporter
Novelty:  0.11329328
Score:  0.553
Data Source:  STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
Score:  0.542
Data Source:  STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.531
Data Source:  STRINGDB
SLC18A3
Tchem
Family:  Transporter
Novelty:  0.00169007
Score:  0.524
Data Source:  STRINGDB
PANX3
Tbio
Family:  IC
Novelty:  0.0071997
Score:  0.518
Data Source:  STRINGDB
MYO5A
Tbio
Novelty:  0.00373224
Score:  0.508
Data Source:  STRINGDB
GID8
Tbio
Novelty:  0.21243963
Score:  0.506
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
48.5
age at menopause
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
48.5
age at menopause
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 9
VGNC:9983
738781
Mouse
MGI:1919107
228993
Rat
RGD:1311940
362287
Dog
solute carrier family 17 member 9
VGNC:46254
485966
Horse
solute carrier family 17 member 9
VGNC:23054
100058964
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 9
Mouse
Rat
Dog
solute carrier family 17 member 9
Horse
solute carrier family 17 member 9
Publication Statistics
PubMed Score 65.69
PubMed score by year
PubTator Score 20.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title