SLC17A8
Vesicular glutamate transporter 3
Protein Summary
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
- ENST00000323346
- ENSP00000316909
- ENSG00000179520
- ENST00000392989
- ENSP00000376715
- VGLUT3
- DFNA25
- VGLUT3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.63 | ||
cellular component | 0.59 | ||
cell line | 0.51 | ||
cell type or tissue | 0.51 | ||
disease | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 190.52 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 190.52 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0