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Tbio
SLC17A3
Sodium-dependent phosphate transport protein 4

Protein Summary
Description
Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360657
  • ENSP00000353873
  • ENSG00000124564
  • ENST00000361703
  • ENSP00000355307
  • ENST00000397060
  • ENSP00000380250

Symbol
  • NPT4
  • NPT4
  • GOUT4
  • UAQTL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
co-expressed gene
0.91
phenotype
0.64
disease
0.6
cell type or tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
Score:  0.839
Data Source:  STRINGDB
SLC22A12
Tclin
Family:  Transporter
Novelty:  0.00318081
Score:  0.807
Data Source:  STRINGDB
SLC22A11
Tclin
Family:  Transporter
Novelty:  0.01343595
Score:  0.792
Data Source:  STRINGDB
SLC37A4
Tchem
Family:  Transporter
Novelty:  0.00787533
Score:  0.764
Data Source:  STRINGDB
PM20D1
Tdark
Family:  Enzyme
Novelty:  0.07205788
Score:  0.75
Data Source:  STRINGDB
SLC16A9
Tbio
Family:  Transporter
Novelty:  0.06564904
Score:  0.737
Data Source:  STRINGDB
SLC22A8
Tclin
Family:  Transporter
Novelty:  0.00291642
Score:  0.731
Data Source:  STRINGDB
SLC22A13
Tbio
Family:  Transporter
Novelty:  0.04702774
Score:  0.725
Data Source:  STRINGDB
SLC22A6
Tclin
Family:  Transporter
Novelty:  0.00389149
Score:  0.701
Data Source:  STRINGDB
LGI2
Tbio
Novelty:  0.09195527
Score:  0.696
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
6
11
6.2
99.8
uric acid measurement
5
5
6
99.4
urinary metabolite measurement
1
5
6
96.6
blood metabolite measurement
2
3
3
94.6
low density lipoprotein cholesterol measurement
2
2
2
93.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
11
6.2
99.8
uric acid measurement
6
99.4
urinary metabolite measurement
6
96.6
blood metabolite measurement
3
94.6
low density lipoprotein cholesterol measurement
2
93.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 3
VGNC:7913
462488
Mouse
MGI:2389216
105355
Rat
RGD:628815
266730
Horse
solute carrier family 17 member 3
VGNC:23049
100052814
Cow
solute carrier family 17 member 3
VGNC:34698
519345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 3
Mouse
Rat
Horse
solute carrier family 17 member 3
Cow
solute carrier family 17 member 3
Publication Statistics
PubMed Score 25.58
PubMed score by year
PubTator Score 11.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title