Tbio SLC17A1 Sodium-dependent phosphate transport protein 1

Protein Summary

Description

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney (PubMed:27906618).

Uniprot Accession IDs

• Q14916
• A8K418
• O60761
• Q13783
• Q3MIP5
• Q5MJP8
• Q5TB83
• Q96KL8

Gene Name

• SLC17A1

Ensembl ID

• ENST00000244527
• ENSP00000244527
• ENSG00000124568
• ENST00000468082
• ENSP00000420546
• ENST00000476801
• ENSP00000420614

Symbol

• NPT1
• NPT1
• NPT-1
• NAPI-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
gene perturbation	0.9
co-expressed gene	0.85
phenotype	0.78
disease	0.63

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium-dependent Phosphate Transport Protein 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc17 Phosphate And Organic Anion Transporter Family / Type I Sodium-phosphate Co-transporters / Sodium-dependent Phosphate Transport Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.81   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.81   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0