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Tbio
SLC17A1
Sodium-dependent phosphate transport protein 1

Protein Summary
Description
Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney (PubMed:27906618).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244527
  • ENSP00000244527
  • ENSG00000124568
  • ENST00000468082
  • ENSP00000420546
  • ENST00000476801
  • ENSP00000420614

Symbol
  • NPT1
  • NPT1
  • NPT-1
  • NAPI-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
gene perturbation
0.9
co-expressed gene
0.85
phenotype
0.78
disease
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.37   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.37   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
PDZK1
Tbio
Novelty:  0.01129974
Score:  0.891
Data Source:  STRINGDB
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
Score:  0.849
Data Source:  STRINGDB
SLC22A12
Tclin
Family:  Transporter
Novelty:  0.00318081
Score:  0.845
Data Source:  STRINGDB
SLC22A11
Tclin
Family:  Transporter
Novelty:  0.01343595
Score:  0.839
Data Source:  STRINGDB
SLC34A1
Tchem
Family:  Transporter
Novelty:  0.00805088
Score:  0.823
Data Source:  STRINGDB
SLC25A3
Tbio
Family:  Transporter
Novelty:  0.00530277
Score:  0.808
Data Source:  STRINGDB
SLC34A2
Tchem
Family:  Transporter
Novelty:  0.00601743
Score:  0.806
Data Source:  STRINGDB
SLC18B1
Tdark
Family:  Transporter
Novelty:  0.25084245
Score:  0.804
Data Source:  STRINGDB
SLC22A6
Tclin
Family:  Transporter
Novelty:  0.00389149
Score:  0.804
Data Source:  STRINGDB
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
Score:  0.764
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Organic anion transporters (R-HSA-428643)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Organic anion transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Organic anion transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
6
11
6.2
99.4
uric acid measurement
5
5
6
98.1
urinary metabolite measurement
1
5
6
94.9
blood metabolite measurement
2
3
3
91.6
2
3
0
1.1
88.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
11
6.2
99.4
uric acid measurement
6
98.1
urinary metabolite measurement
6
94.9
blood metabolite measurement
3
91.6
0
1.1
88.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 1
VGNC:7911
462487
Macaque
solute carrier family 17 member 1
694338
Mouse
MGI:103209
20504
Dog
solute carrier family 17 member 1
VGNC:46248
100683700
Horse
solute carrier family 17 member 1
VGNC:23047
100068069
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 1
Macaque
solute carrier family 17 member 1
Mouse
Dog
solute carrier family 17 member 1
Horse
solute carrier family 17 member 1
Publication Statistics
PubMed Score 75.37
PubMed score by year
PubTator Score 49.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title