SLC17A1
Sodium-dependent phosphate transport protein 1
Protein Summary
Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney (PubMed:27906618).
- ENST00000244527
- ENSP00000244527
- ENSG00000124568
- ENST00000468082
- ENSP00000420546
- ENST00000476801
- ENSP00000420614
- NPT1
- NPT1
- NPT-1
- NAPI-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.93 | ||
gene perturbation | 0.9 | ||
co-expressed gene | 0.85 | ||
phenotype | 0.78 | ||
disease | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.37 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.37 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (49)
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Organic anion transporters | ||||
Reactome | SLC-mediated transmembrane transport | ||||
Reactome | Transport of inorganic cations/anions and amino acids/oligopeptides | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Organic anion transporters | ||||
SLC-mediated transmembrane transport | ||||
Transport of inorganic cations/anions and amino acids/oligopeptides | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (3)
Components (6)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (49)
Items per page:
1 – 5 of 49
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 9 | 6 | 11 | 6.2 | 99.4 | ||||
uric acid measurement | 5 | 5 | 6 | 98.1 | |||||
urinary metabolite measurement | 1 | 5 | 6 | 94.9 | |||||
blood metabolite measurement | 2 | 3 | 3 | 91.6 | |||||
2 | 3 | 0 | 1.1 | 88.4 | |||||
Items per page:
1 – 5 of 49
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 11 | 6.2 | 99.4 | ||||
uric acid measurement | 6 | 98.1 | |||||
urinary metabolite measurement | 6 | 94.9 | |||||
blood metabolite measurement | 3 | 91.6 | |||||
0 | 1.1 | 88.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 17 member 1 | VGNC:7911 | 462487 | |||||
Macaque | solute carrier family 17 member 1 | 694338 | ||||||
Mouse | MGI:103209 | 20504 | ||||||
Dog | solute carrier family 17 member 1 | VGNC:46248 | 100683700 | |||||
Horse | solute carrier family 17 member 1 | VGNC:23047 | 100068069 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 17 member 1 | |||||
Macaque | solute carrier family 17 member 1 | |||||
Mouse | ||||||
Dog | solute carrier family 17 member 1 | |||||
Horse | solute carrier family 17 member 1 | |||||
Publication Statistics
PubMed Score 75.37
PubMed score by year
PubTator Score 49.58
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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