You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC16A2
Monocarboxylate transporter 8

Protein Summary
Description
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000587091
  • ENSP00000465734
  • ENSG00000147100

Symbol
  • MCT8
  • XPCT
  • AHDS
  • MCT7
  • MCT8
  • XPCT
  • MCT 7
  • MCT 8
  • MRX22
  • DXS128
  • DXS128E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
PubMedID
0.77
histone modification site profile
0.69
disease perturbation
0.68
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.44   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.44   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.997955482
p_ni:  0.002042343
p_wrong:  0.000002175
Score:  0.187
Data Source:  BioPlex,STRINGDB
TEX29
Tdark
Novelty:  2.30568043
p_int:  0.996814618
p_ni:  0.001928898
p_wrong:  0.001256484
Score:  0.309
Data Source:  BioPlex,STRINGDB
SLCO1C1
Tbio
Family:  Transporter
Novelty:  0.01175291
Score:  0.895
Data Source:  STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
Score:  0.809
Data Source:  STRINGDB
THRA
Tclin
Family:  NR
Novelty:  0.00171027
Score:  0.761
Data Source:  STRINGDB
DIO2
Tbio
Family:  Enzyme
Novelty:  0.00173094
Score:  0.744
Data Source:  STRINGDB
SERPINA7
Tbio
Novelty:  0.00078476
Score:  0.71
Data Source:  STRINGDB
DIO3
Tbio
Family:  Enzyme
Novelty:  0.0047888
Score:  0.698
Data Source:  STRINGDB
SLC7A3
Tbio
Family:  Transporter
Novelty:  0.00779949
Score:  0.667
Data Source:  STRINGDB
TRH
Tbio
Novelty:  0.00052673
Score:  0.659
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of organic anions
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of organic anions
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
3.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 16 member 2
703252
Mouse
MGI:1203732
20502
Rat
RGD:628608
259248
Dog
solute carrier family 16 member 2
VGNC:46241
491964
Horse
solute carrier family 16 member 2
VGNC:23041
100059100
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 16 member 2
Mouse
Rat
Dog
solute carrier family 16 member 2
Horse
solute carrier family 16 member 2
Publication Statistics
PubMed Score 336.44
PubMed score by year
PubTator Score 177.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title