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Tbio
SLC16A11
Monocarboxylate transporter 11

Protein Summary
Description
Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308009
  • ENSP00000310490
  • ENSG00000174326

Symbol
  • MCT11
  • MCT11
  • MCT 11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
PubMedID
0.54
gene perturbation
0.53
cellular component
0.5
molecular function
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
EMB
Tbio
Novelty:  0.00135577
p_int:  0.999994912
p_ni:  0.000005087
p_wrong:  1e-9
Score:  0.398
Data Source:  BioPlex,STRINGDB
H2AFB2
Tdark
Novelty:  0.10410644
p_int:  0.993864943
p_ni:  0.006134098
p_wrong:  9.6e-7
Score:  0.685
Data Source:  BioPlex,STRINGDB
TOMM34
Tbio
Novelty:  0.05433718
p_int:  0.908291635
p_ni:  0.091014434
p_wrong:  0.000693931
Score:  0.219
Data Source:  BioPlex,STRINGDB
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.793598351
p_ni:  0.206401649
Score:  0.189
Data Source:  BioPlex,STRINGDB
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
Score:  0.53
Data Source:  STRINGDB
R3HDML
Tdark
Family:  Enzyme
Novelty:  0.1121208
Score:  0.527
Data Source:  STRINGDB
ALOX12
Tchem
Family:  Enzyme
Novelty:  0.00287761
Score:  0.505
Data Source:  STRINGDB
CDC123
Tbio
Novelty:  0.05599841
Score:  0.503
Data Source:  STRINGDB
SLC35F5
Tdark
Family:  Transporter
Novelty:  0.53360993
Score:  0.493
Data Source:  STRINGDB
C2CD4A
Tbio
Novelty:  0.1392162
Score:  0.486
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
2
1.2
93.1
alkaline phosphatase measurement
1
2
2
89.6
blood metabolite measurement
1
1
1
75.7
total cholesterol measurement
1
1
1
74.4
body height
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.2
93.1
alkaline phosphatase measurement
2
89.6
blood metabolite measurement
1
75.7
total cholesterol measurement
1
74.4
body height
1
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 16 member 11
VGNC:9613
468446
Macaque
solute carrier family 16 member 11
721775
Mouse
MGI:2663709
216867
Rat
RGD:1311125
287450
Dog
solute carrier family 16 member 11
VGNC:46237
489460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 16 member 11
Macaque
solute carrier family 16 member 11
Mouse
Rat
Dog
solute carrier family 16 member 11
Publication Statistics
PubMed Score 15.00
PubMed score by year
PubTator Score 9.52
PubTator score by year
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Related Publications
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PMID
Year
Title