SLC16A11
Monocarboxylate transporter 11
Protein Summary
Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).
- ENST00000308009
- ENSP00000310490
- ENSG00000174326
- MCT11
- MCT11
- MCT 11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.68 | ||
PubMedID | 0.54 | ||
gene perturbation | 0.53 | ||
cellular component | 0.5 | ||
molecular function | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (29)
EMB
Novelty: 0.00135577
p_int: 0.999994912
p_ni: 0.000005087
p_wrong: 1e-9
Score: 0.398
Data Source: BioPlex,STRINGDB
H2AFB2
Novelty: 0.10410644
p_int: 0.993864943
p_ni: 0.006134098
p_wrong: 9.6e-7
Score: 0.685
Data Source: BioPlex,STRINGDB
TOMM34
Novelty: 0.05433718
p_int: 0.908291635
p_ni: 0.091014434
p_wrong: 0.000693931
Score: 0.219
Data Source: BioPlex,STRINGDB
UFSP2
Family: Enzyme
Novelty: 0.12630722
p_int: 0.793598351
p_ni: 0.206401649
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (3)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 8 | 2 | 1.2 | 93.1 | |||||
alkaline phosphatase measurement | 1 | 2 | 2 | 89.6 | |||||
blood metabolite measurement | 1 | 1 | 1 | 75.7 | |||||
total cholesterol measurement | 1 | 1 | 1 | 74.4 | |||||
body height | 1 | 1 | 1 | 56.8 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1.2 | 93.1 | |||||
alkaline phosphatase measurement | 2 | 89.6 | |||||
blood metabolite measurement | 1 | 75.7 | |||||
total cholesterol measurement | 1 | 74.4 | |||||
body height | 1 | 56.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 16 member 11 | VGNC:9613 | 468446 | |||||
Macaque | solute carrier family 16 member 11 | 721775 | ||||||
Mouse | MGI:2663709 | 216867 | ||||||
Rat | RGD:1311125 | 287450 | ||||||
Dog | solute carrier family 16 member 11 | VGNC:46237 | 489460 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 16 member 11 | |||||
Macaque | solute carrier family 16 member 11 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 16 member 11 | |||||
Publication Statistics
PubMed Score 15.00
PubMed score by year
PubTator Score 9.52
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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