Tbio SLC15A4 Solute carrier family 15 member 4

Protein Summary

Description

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.

Uniprot Accession IDs

• Q8N697
• A6H8Y9
• B3KTK1
• Q71M34
• Q7Z5F8
• Q8TAH0

Gene Name

• SLC15A4

Ensembl ID

• ENST00000266771
• ENSP00000266771
• ENSG00000139370

Symbol

• PHT1
• PTR4
• PHT1
• PTR4
• FP12591

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
transcription factor perturbation	0.88
virus perturbation	0.85
transcription factor binding site profile	0.79
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / Transporter / Solute Carrier Family 15 Member 4

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc15 Family Of Peptide Transporters / Solute Carrier Family 15 Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.54   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.54   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (5)

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (138)

Explore Interacting Targets

1 – 10 of 138

• See Interactions on String-DB

CXorf21

Tdark

Novelty:  0.30533562

p_int:  0.999909668

p_ni:  0.000090332

Score:  0.661

Data Source:  BioPlex,STRINGDB

SLC22A2

Tchem

Family:  Transporter

Novelty:  0.00439263

p_int:  0.99909149

p_ni:  0.000878504

p_wrong:  0.000030006

Data Source:  BioPlex

NKAIN1

Tdark

Family:  Enzyme

Novelty:  0.52190272

p_int:  0.998834133

p_ni:  0.001120224

p_wrong:  0.000045643

Data Source:  BioPlex

UPK1A

Tbio

Novelty:  0.01748122

p_int:  0.99879807

p_ni:  0.001201889

p_wrong:  4.1e-8

Data Source:  BioPlex

GPR21

Tdark

Family:  GPCR

Novelty:  0.90865557

p_int:  0.997806742

p_ni:  0.002164641

p_wrong:  0.000028617

Data Source:  BioPlex

LRRC55

Tbio

Family:  IC

Novelty:  0.25121277

p_int:  0.997665797

p_ni:  0.002256538

p_wrong:  0.000077666

Data Source:  BioPlex

LGALS3

Tchem

Novelty:  0.00032754

p_int:  0.99614208

p_ni:  0.003850162

p_wrong:  0.000007758

Data Source:  BioPlex

PTGIR

Tclin

Family:  GPCR

Novelty:  0.0091906

p_int:  0.992249258

p_ni:  0.007726707

p_wrong:  0.000024036

Data Source:  BioPlex

TNFRSF10C

Tbio

Novelty:  0.0088942

p_int:  0.984982877

p_ni:  0.012733198

p_wrong:  0.002283925

Data Source:  BioPlex

GORASP1

Tbio

Novelty:  0.02332405

p_int:  0.984699119

p_ni:  0.015204515

p_wrong:  0.000096366

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (7)

Immune System (R-HSA-168256)

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5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695
Reactome	Proton/oligopeptide cotransporters	4 targets	R-HSA-427975
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695
Proton/oligopeptide cotransporters	4 targets	R-HSA-427975
SLC-mediated transmembrane transport	250 targets	R-HSA-425407

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (4)

Components (4)

Processes (4)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
L-histidine transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oligopeptide transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
peptide transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
peptide:proton symporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systemic lupus erythematosus	EFO_0002690	6	5	0	1.2	78.5
basophil percentage of leukocytes	EFO_0007992	1	1	1		67.9
basophil count	EFO_0005090	2	1	2		57.8
age at onset	EFO_0004847	1	1	0	2.9	24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systemic lupus erythematosus	EFO_0002690	0	1.2	78.5
basophil percentage of leukocytes	EFO_0007992	1		67.9
basophil count	EFO_0005090	2		57.8
age at onset	EFO_0004847	0	2.9	24.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Membrane
Peptide transport
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Symport
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
basophil count
basophil percentage of leukocytes
systemic lupus erythematosus

MGI Phenotype Find Similar Targets

No Header	No Header
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 15 member 4	VGNC:8534	452366
Macaque	solute carrier family 15 member 4		716359
Mouse	solute carrier family 15, member 4	MGI:2140796	100561
Rat	solute carrier family 15 member 4	RGD:708469	246280
Dog	solute carrier family 15 member 4	VGNC:52967	610055

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 15 member 4
Macaque	solute carrier family 15 member 4
Mouse	solute carrier family 15, member 4
Rat	solute carrier family 15 member 4
Dog	solute carrier family 15 member 4

Publication Statistics

PubMed Score 81.54

PubMed score by year

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PubTator Score 26.04

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (11)

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10

0 of 0

PMID	Year	Title