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Tbio
SLC15A3
Solute carrier family 15 member 3

Protein Summary
Description
Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227880
  • ENSP00000227880
  • ENSG00000110446

Symbol
  • OCTP
  • PHT2
  • PTR3
  • OCTP
  • PHT2
  • PTR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.7
tissue sample
0.7
cellular component
0.67
tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
CD6
Tbio
Novelty:  0.00309541
Score:  0.756
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.67
Data Source:  STRINGDB
CD5
Tbio
Novelty:  0.00032883
Score:  0.654
Data Source:  STRINGDB
NOD2
Tclin
Novelty:  0.00059089
Score:  0.63
Data Source:  STRINGDB
SLC37A2
Tbio
Family:  Transporter
Novelty:  0.08172762
Score:  0.587
Data Source:  STRINGDB
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
Score:  0.575
Data Source:  STRINGDB
CSF1R
Tclin
Family:  Kinase
Novelty:  0.00064143
Score:  0.565
Data Source:  STRINGDB
PTCHD3
Tbio
Novelty:  0.00081643
Score:  0.543
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.533
Data Source:  STRINGDB
CD14
Tbio
Novelty:  0.00872424
Score:  0.529
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Proton/oligopeptide cotransporters (R-HSA-427975)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Proton/oligopeptide cotransporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Proton/oligopeptide cotransporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.2
90.4
cathepsin L1 measurement
1
1
1
77.3
CD6 measurement
1
1
1
67.3
2
1
0
1.1
61.4
1
1
0
1.1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
90.4
cathepsin L1 measurement
1
77.3
CD6 measurement
1
67.3
0
1.1
61.4
0
1.1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 15 member 3
VGNC:7757
451229
Macaque
solute carrier family 15 member 3
696060
Mouse
MGI:1929691
65221
Rat
RGD:628663
246239
Dog
solute carrier family 15 member 3
VGNC:52046
612351
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 15 member 3
Macaque
solute carrier family 15 member 3
Mouse
Rat
Dog
solute carrier family 15 member 3
Publication Statistics
PubMed Score 46.07
PubMed score by year
PubTator Score 12.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title