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Tdark
SLC12A9
Solute carrier family 12 member 9

Protein Summary
Description
May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354161
  • ENSP00000275730
  • ENSG00000146828
  • ENST00000415287
  • ENSP00000413796
  • ENST00000540482
  • ENSP00000443702

Symbol
  • CCC6
  • CIP1
  • CCC6
  • CIP1
  • WO3.3
  • hCCC6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.84
kinase perturbation
0.76
tissue sample
0.74
transcription factor
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.997824085
p_ni:  0.002175914
p_wrong:  1e-9
Data Source:  BioPlex
PTH1R
Tclin
Family:  GPCR
Novelty:  0.00413989
p_int:  0.994647764
p_ni:  0.005352236
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.989452589
p_ni:  0.010547411
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.983114078
p_ni:  0.016885771
p_wrong:  1.51e-7
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.976802613
p_ni:  0.023197309
p_wrong:  7.8e-8
Data Source:  BioPlex
SEMA7A
Tbio
Novelty:  0.00741605
p_int:  0.974666645
p_ni:  0.025333354
p_wrong:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.965222457
p_ni:  0.034777543
Data Source:  BioPlex
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.952489035
p_ni:  0.047510964
Data Source:  BioPlex
KCNA10
Tclin
Family:  IC
Novelty:  0.05708808
p_int:  0.945990289
p_ni:  0.054009711
Data Source:  BioPlex
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.938649609
p_ni:  0.06135022
p_wrong:  1.71e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
3
8
8.6
94
hair color
1
3
0
1.1
92.5
heart rate response to recovery post exercise
5
2
5
92.4
heart rate response to exercise
2
2
2
84.7
total cholesterol measurement
3
4
4
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
8
8.6
94
hair color
0
1.1
92.5
heart rate response to recovery post exercise
5
92.4
heart rate response to exercise
2
84.7
total cholesterol measurement
4
82
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 9
VGNC:8754
463611
Macaque
solute carrier family 12 member 9
713119
Mouse
MGI:1933532
83704
Rat
RGD:620747
171443
Dog
solute carrier family 12 member 9
VGNC:46226
489829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 9
Macaque
solute carrier family 12 member 9
Mouse
Rat
Dog
solute carrier family 12 member 9
Publication Statistics
PubMed Score 8.92
PubMed score by year
PubTator Score 2.49
PubTator score by year
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Related Publications
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PMID
Year
Title