You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC12A8
Solute carrier family 12 member 8

Protein Summary
Description
Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393469
  • ENSP00000377112
  • ENSG00000221955
  • ENST00000430155
  • ENSP00000415713
  • ENST00000469902
  • ENSP00000418783

Symbol
  • CCC9
  • CCC9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
transcription factor
0.73
histone modification site profile
0.72
PubMedID
0.71
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.88   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.88   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
NGEF
Tbio
Novelty:  0.04628547
p_int:  0.999982989
p_ni:  0.00001701
p_wrong:  1e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
CSTA
Tbio
Novelty:  0.00453121
Score:  0.902
Data Source:  STRINGDB
Q29963
Tbio
Novelty:  0.00698601
Score:  0.712
Data Source:  STRINGDB
P30505
Tbio
Novelty:  0.00698601
Score:  0.712
Data Source:  STRINGDB
P10321
Tbio
Novelty:  0.00698601
Score:  0.712
Data Source:  STRINGDB
P30499
Tbio
Novelty:  0.00698601
Score:  0.712
Data Source:  STRINGDB
P30510
Tbio
Novelty:  0.00698601
Score:  0.712
Data Source:  STRINGDB
P30508
Tbio
Novelty:  0.00698601
Score:  0.712
Data Source:  STRINGDB
Q95604
Tbio
Novelty:  0.00698601
Score:  0.712
Data Source:  STRINGDB
P04222
Tbio
Novelty:  0.00698601
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
2
1
89.7
reticulocyte count
2
2
2
70.4
reticulocyte measurement
2
2
2
66.6
mean corpuscular volume
1
1
1
65.6
tonsillectomy risk measurement
1
1
0
1.1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
89.7
reticulocyte count
2
70.4
reticulocyte measurement
2
66.6
mean corpuscular volume
1
65.6
tonsillectomy risk measurement
0
1.1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 8
VGNC:7996
460649
Mouse
MGI:2443672
171286
Rat
RGD:628730
266733
Dog
solute carrier family 12 member 8
VGNC:46225
488016
Horse
solute carrier family 12 member 8
VGNC:23024
100070338
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 8
Mouse
Rat
Dog
solute carrier family 12 member 8
Horse
solute carrier family 12 member 8
Publication Statistics
PubMed Score 17.88
PubMed score by year
PubTator Score 4.79
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title