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Tbio
SLC12A7
Solute carrier family 12 member 7

Protein Summary
Description
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264930
  • ENSP00000264930
  • ENSG00000113504

Symbol
  • KCC4
  • KCC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
molecular function
0.76
cell line
0.7
PubMedID
0.7
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.2   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.2   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.99999392
p_ni:  0.00000608
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999978277
p_ni:  0.000021723
Score:  0.204
Data Source:  BioPlex,STRINGDB
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.999888755
p_ni:  0.000111245
Score:  0.167
Data Source:  BioPlex,STRINGDB
LGALS9C
Tdark
Novelty:  0.29969898
p_int:  0.999666469
p_ni:  0.000333531
Score:  0.692
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999580667
p_ni:  0.000419329
p_wrong:  4e-9
Score:  0.317
Data Source:  BioPlex,STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
p_int:  0.990030857
p_ni:  0.009968784
p_wrong:  3.59e-7
Data Source:  BioPlex
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.976566899
p_ni:  0.023433101
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.973050897
p_ni:  0.026935115
p_wrong:  0.000013988
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.97174493
p_ni:  0.025877175
p_wrong:  0.002377895
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.952417683
p_ni:  0.047582312
p_wrong:  5e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cation-coupled Chloride cotransporters (R-HSA-426117)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cation-coupled Chloride cotransporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cation-coupled Chloride cotransporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
7
6
8
97.8
red blood cell distribution width
6
21
31
97.8
mean corpuscular volume
3
3
3
83.5
hemoglobin measurement
3
2
3
78
2
2
0
1.1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
8
97.8
red blood cell distribution width
31
97.8
mean corpuscular volume
3
83.5
hemoglobin measurement
3
78
0
1.1
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 7
VGNC:53272
750819
Macaque
solute carrier family 12 member 7
709581
Mouse
MGI:1342283
20499
Rat
RGD:1359672
308069
Dog
solute carrier family 12 member 7
VGNC:46224
488069
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 7
Macaque
solute carrier family 12 member 7
Mouse
Rat
Dog
solute carrier family 12 member 7
Publication Statistics
PubMed Score 45.20
PubMed score by year
PubTator Score 19.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title