Tchem SLC12A5 Solute carrier family 12 member 5

Protein Summary

Description

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• Q9H2X9
• A2RTX2
• Q5VZ41
• Q9H4Z0
• Q9ULP4

Gene Name

• SLC12A5

Ensembl ID

• ENST00000243964
• ENSP00000243964
• ENSG00000124140
• ENST00000454036
• ENSP00000387694

Symbol

• KCC2
• KIAA1176
• KCC2
• EIG14
• hKCC2
• EIEE34

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.7
small molecule perturbation	0.62
gene perturbation	0.6
molecular function	0.6
microRNA	0.59

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc12 Family Of Cation-coupled Chloride Transporters / Solute Carrier Family 12 Member 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.53   (req: < 5)

Gene RIFs: 58   (req: <= 3)

Antibodies: 311   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.53   (req: >= 5)

Gene RIFs: 58   (req: > 3)

Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0