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Tbio
SLC12A4
Solute carrier family 12 member 4

Protein Summary
Description
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316341
  • ENSP00000318557
  • ENSG00000124067
  • ENST00000422611
  • ENSP00000395983
  • ENST00000537830
  • ENSP00000445962
  • ENST00000541864
  • ENSP00000438334
  • ENST00000576616
  • ENSP00000458902

Symbol
  • KCC1
  • KCC1
  • hKCC1
  • CTC-479C5.17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
co-expressed gene
0.94
transcription factor
0.89
disease perturbation
0.87
transcription factor binding site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.8   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.8   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999996159
p_ni:  0.000003841
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.999857745
p_ni:  0.000142253
p_wrong:  2e-9
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999853447
p_ni:  0.000146552
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
LYPD6
Tbio
Novelty:  0.13867181
p_int:  0.99964465
p_ni:  0.00035535
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.998442985
p_ni:  0.001557008
p_wrong:  7e-9
Score:  0.514
Data Source:  BioPlex,STRINGDB
LGALS9C
Tdark
Novelty:  0.29969898
p_int:  0.998046182
p_ni:  0.001953817
p_wrong:  1e-9
Score:  0.723
Data Source:  BioPlex,STRINGDB
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.996099758
p_ni:  0.003900239
p_wrong:  2e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
OR10S1
Tdark
Family:  oGPCR
Novelty:  2.23425255
p_int:  0.993291418
p_ni:  0.006706913
p_wrong:  0.00000167
Data Source:  BioPlex
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.993104668
p_ni:  0.006895332
Data Source:  BioPlex
TNFRSF10A
Tchem
Novelty:  0.0003383
p_int:  0.991599827
p_ni:  0.008400164
p_wrong:  9e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cation-coupled Chloride cotransporters (R-HSA-426117)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cation-coupled Chloride cotransporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cation-coupled Chloride cotransporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
22
38
10
99.5
apolipoprotein A 1 measurement
2
7
7
98.8
mean corpuscular volume
1
2
2
90.6
sleep duration
2
2
3
84.1
red blood cell density measurement
1
1
1
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
38
10
99.5
apolipoprotein A 1 measurement
7
98.8
mean corpuscular volume
2
90.6
sleep duration
3
84.1
red blood cell density measurement
1
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 4
VGNC:9012
454181
Macaque
solute carrier family 12 member 4
701196
Mouse
MGI:1309465
20498
Rat
RGD:3687
29501
Dog
solute carrier family 12 member 4
VGNC:46221
479679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 4
Macaque
solute carrier family 12 member 4
Mouse
Rat
Dog
solute carrier family 12 member 4
Publication Statistics
PubMed Score 90.80
PubMed score by year
PubTator Score 40.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title