SLC12A2
Solute carrier family 12 member 2
Protein Summary
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- ENST00000262461
- ENSP00000262461
- ENSG00000064651
- ENST00000343225
- ENSP00000340878
- NKCC1
- BSC
- BSC2
- NKCC1
- PPP1R141
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
histone modification site profile | 0.85 | ||
disease perturbation | 0.83 | ||
virus perturbation | 0.83 | ||
gene perturbation | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1026.48 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 338 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1026.48 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 338 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3