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Tbio
SLC11A1
Natural resistance-associated macrophage protein 1

Protein Summary
Description
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233202
  • ENSP00000233202
  • ENSG00000018280

Symbol
  • LSH
  • NRAMP
  • NRAMP1
  • LSH
  • NRAMP
  • NRAMP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.93
cellular component
0.89
molecular function
0.84
biological term
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 912.7   (req: < 5)
Gene RIFs: 130   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 912.7   (req: >= 5)
Gene RIFs: 130   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.95
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.943
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.94
Data Source:  STRINGDB
CLEC4D
Tbio
Novelty:  0.04119682
Score:  0.934
Data Source:  STRINGDB
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.934
Data Source:  STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
Score:  0.933
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.932
Data Source:  STRINGDB
ATP11A
Tbio
Family:  Transporter
Novelty:  0.05334905
Score:  0.931
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion influx/efflux at host-pathogen interface
Reactome
Metal ion SLC transporters
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Ion influx/efflux at host-pathogen interface
Metal ion SLC transporters
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (54)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
95.7
reticulocyte measurement
3
4
6
92.2
reticulocyte count
2
2
2
90.4
body height
2
2
2
86.8
hematocrit
1
1
1
83.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
95.7
reticulocyte measurement
6
92.2
reticulocyte count
2
90.4
body height
2
86.8
hematocrit
1
83.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 11 member 1
VGNC:9054
741434
Macaque
solute carrier family 11 member 1
701025
Mouse
MGI:1345275
18173
Rat
RGD:1601463
316519
Dog
solute carrier family 11 member 1
VGNC:46216
478909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 11 member 1
Macaque
solute carrier family 11 member 1
Mouse
Rat
Dog
solute carrier family 11 member 1
Publication Statistics
PubMed Score 912.70
PubMed score by year
PubTator Score 294.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title