Tbio SLBP Histone RNA hairpin-binding protein

Protein Summary

Description

RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs. This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14493
• B3KRJ5

Gene Name

• SLBP

Ensembl ID

• ENST00000429429
• ENSP00000406322
• ENSG00000163950
• ENST00000489418
• ENSP00000417686

Symbol

• HBP
• HBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.97
kinase perturbation	0.96
ligand (protein) perturbation	0.96
transcription factor perturbation	0.91
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Histone Rna Hairpin-binding Protein

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Histone Rna Hairpin-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.21   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.21   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (205)

Explore Interacting Targets

1 – 10 of 205

• See Interactions on String-DB

P4HA3

Tbio

Family:  Enzyme

Novelty:  0.03832564

p_int:  0.999992292

p_ni:  0.000004018

p_wrong:  0.000003691

Score:  0.177

Data Source:  BioPlex,STRINGDB

NDOR1

Tbio

Family:  Enzyme

Novelty:  0.07400532

p_int:  0.999981049

p_ni:  0.000012129

p_wrong:  0.000006823

Data Source:  BioPlex

ZFC3H1

Tbio

Novelty:  0.17313739

p_int:  0.999973154

p_ni:  0.000013797

p_wrong:  0.000013048

Score:  0.244

Data Source:  BioPlex,STRINGDB

GSTM3

Tbio

Family:  Enzyme

Novelty:  0.0078192

p_int:  0.989009236

p_ni:  0.000034424

p_wrong:  0.01095634

Score:  0.237

Data Source:  BioPlex,STRINGDB

ERI1

Tbio

Family:  Enzyme

Novelty:  0.00959105

Score:  0.998

Data Source:  STRINGDB

LSM10

Tbio

Novelty:  0.16403413

Score:  0.99

Data Source:  STRINGDB

LSM11

Tbio

Novelty:  0.10694492

Score:  0.986

Data Source:  STRINGDB

MIF4GD

Tbio

Novelty:  0.04798623

Score:  0.984

Data Source:  STRINGDB

NASP

Tbio

Novelty:  0.00902599

Score:  0.984

Data Source:  STRINGDB

ZNF473

Tbio

Family:  TF

Novelty:  0.07957644

Score:  0.975

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (10)

Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (4)

Components (7)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
mRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
histone pre-mRNA DCP binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
histone pre-mRNA stem-loop binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	3	10	10		90.8
type II diabetes mellitus	EFO_0001360	6	3	3	1.1	88.6
bladder carcinoma	EFO_0000292	4	2	0	1.2	79.3
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		64.9
mean reticulocyte volume	EFO_0010701	1	1	1		63.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	10		90.8
type II diabetes mellitus	EFO_0001360	3	1.1	88.6
bladder carcinoma	EFO_0000292	0	1.2	79.3
serum gamma-glutamyl transferase measurement	EFO_0004532	1		64.9
mean reticulocyte volume	EFO_0010701	1		63.7

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Isopeptide bond
mRNA processing
Nucleus
Phosphoprotein
Reference proteome
Ribonucleoprotein

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
bladder carcinoma
BMI-adjusted hip circumference
body height
gait measurement
hip circumference
mean corpuscular volume
mean reticulocyte volume
osteoarthritis
osteoarthritis, hip

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	stem-loop binding protein	VGNC:49205	471120
Macaque	stem-loop binding protein		722546
Mouse	stem-loop binding protein	MGI:108402	20492
Rat	stem-loop binding protein	RGD:1584682	681062
Dog	stem-loop binding protein	VGNC:46210	488810

Species	Name	OMA	EggNOG	Inparanoid
Chimp	stem-loop binding protein
Macaque	stem-loop binding protein
Mouse	stem-loop binding protein
Rat	stem-loop binding protein
Dog	stem-loop binding protein

Publication Statistics

PubMed Score 140.21

PubMed score by year

Reset Zoom

PubTator Score 63.27

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (52)

GeneRif Annotations (29)

Items per page:

10

0 of 0

PMID	Year	Title