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Tbio
SLAMF8
SLAM family member 8

Protein Summary
Description
May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289707
  • ENSP00000289707
  • ENSG00000158714
  • ENST00000368104
  • ENSP00000357084

Symbol
  • BLAME
  • BLAME
  • CD353
  • SBBI42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.59
tissue sample
0.58
gene perturbation
0.57
biological process
0.44
microRNA
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.72   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.72   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
FBP1
Tchem
Family:  Enzyme
Novelty:  0.0029987
p_int:  0.982810996
p_ni:  0.017188961
p_wrong:  4.2e-8
Score:  0.557
Data Source:  BioPlex,STRINGDB
SLAMF9
Tbio
Novelty:  0.13795139
Score:  0.797
Data Source:  STRINGDB
IGSF9
Tbio
Novelty:  0.01374466
Score:  0.713
Data Source:  STRINGDB
LY9
Tbio
Novelty:  0.01892831
Score:  0.691
Data Source:  STRINGDB
C1QB
Tbio
Novelty:  0.01476497
Score:  0.682
Data Source:  STRINGDB
SLAMF6
Tbio
Novelty:  0.01459284
Score:  0.673
Data Source:  STRINGDB
FCRL6
Tbio
Novelty:  0.19257954
Score:  0.654
Data Source:  STRINGDB
NRROS
Tbio
Novelty:  0.08976002
Score:  0.641
Data Source:  STRINGDB
C1QA
Tbio
Novelty:  0.00987917
Score:  0.637
Data Source:  STRINGDB
FCGR3A
Tclin
Novelty:  0.0004214
Score:  0.616
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
8
13
20
20.7
99.9
mean platelet volume
3
1
3
75.1
bilirubin measurement
1
1
1
61.2
brain measurement
1
1
0
6.6
36.4
cortical surface area measurement
1
1
0
6.2
28.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
20
20.7
99.9
mean platelet volume
3
75.1
bilirubin measurement
1
61.2
brain measurement
0
6.6
36.4
cortical surface area measurement
0
6.2
28.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SLAM family member 8
VGNC:11003
457429
Macaque
SLAM family member 8
719494
Mouse
MGI:1921998
74748
Rat
RGD:1306263
289237
Dog
SLAM family member 8
VGNC:53130
488631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SLAM family member 8
Macaque
SLAM family member 8
Mouse
Rat
Dog
SLAM family member 8
Publication Statistics
PubMed Score 14.72
PubMed score by year
PubTator Score 5.91
PubTator score by year
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Related Publications
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PMID
Year
Title