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Tbio
SKP1
S-phase kinase-associated protein 1

Protein Summary
Description
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353411
  • ENSP00000231487
  • ENSG00000113558
  • ENST00000517625
  • ENSP00000429961
  • ENST00000522552
  • ENSP00000429472
  • ENST00000522855
  • ENSP00000429686

Symbol
  • EMC19
  • OCP2
  • SKP1A
  • TCEB1L
  • OCP2
  • p19A
  • EMC19
  • SKP1A
  • OCP-II
  • TCEB1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
transcription factor perturbation
0.99
kinase perturbation
0.98
co-expressed gene
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.36   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 495   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.36   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0