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Tbio
SKAP1
Src kinase-associated phosphoprotein 1

Protein Summary
Description
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336915
  • ENSP00000338171
  • ENSG00000141293
  • ENST00000584924
  • ENSP00000464311

Symbol
  • SCAP1
  • SKAP55
  • SCAP1
  • SKAP55
  • HEL-S-81p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.65
molecular function
0.6
cell line
0.57
gene perturbation
0.57
disease
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.78   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.78   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
SKAP2
Tbio
Family:  Enzyme
Novelty:  0.00614207
p_int:  0.999998833
p_ni:  0.000001167
Score:  0.193
Data Source:  BioPlex,STRINGDB
PAX3
Tbio
Family:  TF
Novelty:  0.00140464
p_int:  0.999995642
p_ni:  9.3e-8
p_wrong:  0.000004265
Score:  0.173
Data Source:  BioPlex,STRINGDB
NEK1
Tchem
Family:  Kinase
Novelty:  0.0164923
p_int:  0.999991422
p_ni:  0.000008578
Data Source:  BioPlex
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
p_int:  0.999949398
p_ni:  0.000050602
Data Source:  BioPlex
SUGCT
Tbio
Family:  Enzyme
Novelty:  0.0075902
p_int:  0.999943892
p_ni:  0.000041608
p_wrong:  0.0000145
Score:  0.173
Data Source:  BioPlex,STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
p_int:  0.999847047
p_ni:  0.000152953
Data Source:  BioPlex
CFAP410
Tbio
Novelty:  0.0143773
p_int:  0.999630854
p_ni:  0.000369144
p_wrong:  2e-9
Data Source:  BioPlex
NPHP4
Tbio
Novelty:  0.02873746
p_int:  0.999500421
p_ni:  0.000481193
p_wrong:  0.000018387
Score:  0.186
Data Source:  BioPlex,STRINGDB
KSR1
Tbio
Family:  Kinase
Novelty:  0.00691155
p_int:  0.997916549
p_ni:  0.001347322
p_wrong:  0.000736129
Score:  0.187
Data Source:  BioPlex,STRINGDB
RECQL4
Tbio
Family:  Enzyme
Novelty:  0.00576141
p_int:  0.997796652
p_ni:  0.002203348
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Inferred by Curator (IC)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
2
4
88.7
3
2
0
1.1
80.6
heel bone mineral density
2
3
3
77
chronotype measurement
3
3
3
74.6
hemoglobin measurement
1
1
1
72.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
88.7
0
1.1
80.6
heel bone mineral density
3
77
chronotype measurement
3
74.6
hemoglobin measurement
1
72.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
src kinase associated phosphoprotein 1
VGNC:9611
468432
Mouse
MGI:1925723
78473
Rat
RGD:708436
286975
Dog
src kinase associated phosphoprotein 1
VGNC:46196
480543
Cow
src kinase associated phosphoprotein 1
VGNC:54484
506769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
src kinase associated phosphoprotein 1
Mouse
Rat
Dog
src kinase associated phosphoprotein 1
Cow
src kinase associated phosphoprotein 1
Publication Statistics
PubMed Score 34.78
PubMed score by year
PubTator Score 21.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title