You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SKA3
Spindle and kinetochore-associated protein 3

Protein Summary
Description
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298260
  • ENSP00000298260
  • ENSG00000165480
  • ENST00000314759
  • ENSP00000319417
  • ENST00000400018
  • ENSP00000382896

Symbol
  • C13orf3
  • RAMA1
  • RAMA1
  • C13orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.75
transcription factor
0.65
microRNA
0.6
interacting protein
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.37   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.37   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (181)
SKA1
Tbio
Novelty:  0.01777146
p_int:  0.999999994
p_ni:  3e-9
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SKA2
Tbio
Novelty:  0.03605487
p_int:  0.999999868
p_ni:  1.8e-8
p_wrong:  1.14e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
PYCR2
Tbio
Family:  Enzyme
Novelty:  0.05660996
p_int:  0.999999799
p_ni:  2.01e-7
Score:  0.795
Data Source:  BioPlex,STRINGDB
PPP2R2C
Tbio
Family:  Enzyme
Novelty:  0.05453128
p_int:  0.999999697
p_ni:  2.98e-7
p_wrong:  5e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
NOL4
Tbio
Novelty:  0.04108058
p_int:  0.999997627
p_ni:  0.000001502
p_wrong:  8.72e-7
Score:  0.345
Data Source:  BioPlex,STRINGDB
NOL4L
Tbio
Novelty:  0.18372474
p_int:  0.999995542
p_ni:  5.6e-8
p_wrong:  0.000004402
Score:  0.345
Data Source:  BioPlex,STRINGDB
LHFPL2
Tdark
Novelty:  0.85421144
p_int:  0.999945049
p_ni:  0.000039074
p_wrong:  0.000015877
Data Source:  BioPlex
CCDC85B
Tdark
Novelty:  0.02034018
p_int:  0.999870783
p_ni:  0.000129141
p_wrong:  7.6e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
LRRCC1
Tdark
Novelty:  0.14730953
p_int:  0.999402504
p_ni:  0.000002474
p_wrong:  0.000595022
Score:  0.209
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999388037
p_ni:  0.000610301
p_wrong:  0.000001662
Score:  0.281
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spindle and kinetochore associated complex subunit 3
VGNC:5108
452468
Macaque
spindle and kinetochore associated complex subunit 3
702839
Mouse
MGI:3041235
219114
Rat
RGD:1307201
361047
Dog
spindle and kinetochore associated complex subunit 3
VGNC:46195
609400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spindle and kinetochore associated complex subunit 3
Macaque
spindle and kinetochore associated complex subunit 3
Mouse
Rat
Dog
spindle and kinetochore associated complex subunit 3
Publication Statistics
PubMed Score 32.37
PubMed score by year
PubTator Score 9.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title