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Tdark
SIX6OS1
Protein SIX6OS1

Protein Summary
Description
Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321731
  • ENSP00000324920
  • ENSG00000179008

Symbol
  • C14orf39
  • Six6os1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.25   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.25   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
RNF212
Tbio
Family:  Enzyme
Novelty:  0.05189831
Score:  0.728
Data Source:  STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
Score:  0.728
Data Source:  STRINGDB
RAD21L1
Tdark
Novelty:  0.11750397
Score:  0.652
Data Source:  STRINGDB
PRR16
Tdark
Novelty:  0.17809341
Score:  0.62
Data Source:  STRINGDB
SMC1B
Tbio
Novelty:  0.0369537
Score:  0.594
Data Source:  STRINGDB
C3orf38
Tdark
Novelty:  2.10467478
Score:  0.588
Data Source:  STRINGDB
MSH4
Tbio
Novelty:  0.00838156
Score:  0.568
Data Source:  STRINGDB
FIGN
Tbio
Family:  Enzyme
Novelty:  0.02804869
Score:  0.548
Data Source:  STRINGDB
FTCD
Tbio
Family:  Enzyme
Novelty:  0.02266041
Score:  0.542
Data Source:  STRINGDB
SYCE2
Tbio
Novelty:  0.16889301
Score:  0.537
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
4
4
5
93.7
appendicular lean mass
3
3
4
93.3
BMI-adjusted hip circumference
3
7
8
91.6
optic cup area measurement
3
3
5
89.9
heel bone mineral density
3
3
3
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
5
93.7
appendicular lean mass
4
93.3
BMI-adjusted hip circumference
8
91.6
optic cup area measurement
5
89.9
heel bone mineral density
3
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 2.25
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title