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Tbio
SIX3
Homeobox protein SIX3

Protein Summary
Description
Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260653
  • ENSP00000260653
  • ENSG00000138083

Symbol
  • HPE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.95
PubMedID
0.68
microRNA
0.62
co-expressed gene
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.31   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.31   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
PAX6
Tbio
Family:  TF
Novelty:  0.00064695
Score:  0.969
Data Source:  STRINGDB
GMNN
Tbio
Novelty:  0.00436572
Score:  0.876
Data Source:  STRINGDB
OTX2
Tbio
Family:  TF
Novelty:  0.0024536
Score:  0.855
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.839
Data Source:  STRINGDB
VSX2
Tbio
Family:  TF
Novelty:  0.0046733
Score:  0.823
Data Source:  STRINGDB
SHH
Tchem
Novelty:  0.00028347
Score:  0.813
Data Source:  STRINGDB
EYA1
Tbio
Novelty:  0.00585286
Score:  0.802
Data Source:  STRINGDB
LHX2
Tbio
Family:  TF
Novelty:  0.00915095
Score:  0.798
Data Source:  STRINGDB
WNT1
Tbio
Novelty:  0.00124301
Score:  0.792
Data Source:  STRINGDB
EYA4
Tbio
Novelty:  0.01905381
Score:  0.772
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Endoderm Differentiation
WikiPathways
Circadian rhythm related genes
Name
Explore in Pharos
Explore in Source
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Endoderm Differentiation
Circadian rhythm related genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (41)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
7
5
8
94.6
glucose measurement
3
3
3
92.5
alcohol use disorder measurement
6
5
2
6.5
91.5
risk-taking behaviour
4
4
3
1
86.5
smoking status measurement
4
2
3
1
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
8
94.6
glucose measurement
3
92.5
alcohol use disorder measurement
2
6.5
91.5
risk-taking behaviour
3
1
86.5
smoking status measurement
3
1
85.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SIX homeobox 3
VGNC:10762
470367
Macaque
SIX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:10889]
Mouse
MGI:102764
20473
Rat
RGD:620909
78974
Dog
SIX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:10889]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SIX homeobox 3
Macaque
SIX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:10889]
Mouse
Rat
Dog
SIX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:10889]
Publication Statistics
PubMed Score 176.31
PubMed score by year
PubTator Score 189.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title