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Tbio
SIX2
Homeobox protein SIX2

Protein Summary
Description
Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. Dur ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303077
  • ENSP00000304502
  • ENSG00000170577
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
PubMedID
0.68
cell line
0.64
cell type or tissue
0.62
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.32   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.32   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
EYA1
Tbio
Novelty:  0.00585286
p_int:  0.999999999
p_ni:  1e-9
Score:  0.97
Data Source:  BioPlex,STRINGDB
EYA4
Tbio
Novelty:  0.01905381
p_int:  0.999999976
p_ni:  2.3e-8
Score:  0.845
Data Source:  BioPlex,STRINGDB
EYA3
Tbio
Novelty:  0.05588286
p_int:  0.999999924
p_ni:  7.5e-8
Score:  0.898
Data Source:  BioPlex,STRINGDB
ERCC6L
Tbio
Novelty:  0.01959203
p_int:  0.999998721
p_ni:  0.000001279
Score:  0.165
Data Source:  BioPlex,STRINGDB
PRKD1
Tchem
Family:  Kinase
Novelty:  0.00128927
p_int:  0.999996623
p_ni:  5.3e-8
p_wrong:  0.000003325
Score:  0.238
Data Source:  BioPlex,STRINGDB
BCDIN3D
Tbio
Family:  Enzyme
Novelty:  0.1619174
p_int:  0.999747062
p_ni:  0.000252907
p_wrong:  3.1e-8
Score:  0.277
Data Source:  BioPlex,STRINGDB
EYA2
Tbio
Novelty:  0.01972903
p_int:  0.999310733
p_ni:  1.5e-8
p_wrong:  0.000689252
Score:  0.842
Data Source:  BioPlex,STRINGDB
CHMP3
Tbio
Novelty:  0.01958573
p_int:  0.996820298
p_ni:  0.003176063
p_wrong:  0.000003639
Score:  0.159
Data Source:  BioPlex,STRINGDB
CHMP1A
Tbio
Novelty:  0.03969333
p_int:  0.993602606
p_ni:  0.006396824
p_wrong:  5.7e-7
Data Source:  BioPlex
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.989136406
p_ni:  0.010863594
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
7
5
8
94.6
glucose measurement
3
3
3
92.5
alcohol use disorder measurement
6
5
2
6.5
91.5
risk-taking behaviour
4
4
3
1
86.5
smoking status measurement
4
2
3
1
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
8
94.6
glucose measurement
3
92.5
alcohol use disorder measurement
2
6.5
91.5
risk-taking behaviour
3
1
86.5
smoking status measurement
3
1
85.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SIX homeobox 2
VGNC:359
459197
Macaque
SIX homeobox 2
717242
Mouse
MGI:102778
20472
Rat
RGD:1310792
366542
Dog
SIX homeobox 2
VGNC:46191
481357
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SIX homeobox 2
Macaque
SIX homeobox 2
Mouse
Rat
Dog
SIX homeobox 2
Publication Statistics
PubMed Score 112.32
PubMed score by year
PubTator Score 140.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title