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Tbio
SIX1
Homeobox protein SIX1

Protein Summary
Description
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. The protein encoded by this gene is a homeobox protein that is simi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247182
  • ENSP00000247182
  • ENSG00000126778
  • ENST00000645694
  • ENSP00000494686

Symbol
  • BOS3
  • TIP39
  • DFNA23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.89
molecular function
0.84
tissue sample
0.75
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.46   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.46   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
EYA1
Tbio
Novelty:  0.00585286
p_int:  1
Score:  0.983
Data Source:  BioPlex,STRINGDB
EYA4
Tbio
Novelty:  0.01905381
p_int:  0.999999993
p_ni:  6e-9
Score:  0.906
Data Source:  BioPlex,STRINGDB
ERCC6L
Tbio
Novelty:  0.01959203
p_int:  0.999999204
p_ni:  7.59e-7
p_wrong:  3.7e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
MYH3
Tbio
Novelty:  0.00544794
p_int:  0.999979924
p_ni:  0.000020026
p_wrong:  4.9e-8
Score:  0.494
Data Source:  BioPlex,STRINGDB
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.999936308
p_ni:  0.000063682
p_wrong:  1e-8
Score:  0.469
Data Source:  BioPlex,STRINGDB
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.99971968
p_ni:  0.000280315
p_wrong:  6e-9
Score:  0.388
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.824017374
p_ni:  0.000247175
p_wrong:  0.175735451
Data Source:  BioPlex
EYA2
Tbio
Novelty:  0.01972903
Score:  0.963
Data Source:  STRINGDB
DACH1
Tbio
Novelty:  0.00986576
Score:  0.921
Data Source:  STRINGDB
EYA3
Tbio
Novelty:  0.05588286
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (69)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
2
2
88.5
5
3
0
1.1
87.6
BMI-adjusted hip circumference
2
4
4
86.5
appendicular lean mass
3
2
3
85.2
heel bone mineral density
2
3
3
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
88.5
0
1.1
87.6
BMI-adjusted hip circumference
4
86.5
appendicular lean mass
3
85.2
heel bone mineral density
3
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102780
20471
Rat
RGD:620906
114634
Dog
SIX homeobox 1
VGNC:46190
490719
Cow
SIX homeobox 1
VGNC:54483
511371
Pig
SIX homeobox 1
100156847
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SIX homeobox 1
Cow
SIX homeobox 1
Pig
SIX homeobox 1
Publication Statistics
PubMed Score 283.46
PubMed score by year
PubTator Score 257.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title