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Tchem
SIRT6
NAD-dependent protein deacetylase sirtuin-6

Protein Summary
Description
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RB ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305232
  • ENSP00000305310
  • ENSG00000077463
  • ENST00000337491
  • ENSP00000337332

Symbol
  • SIR2L6
  • SIR2L6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.78
cellular component
0.73
biological term
0.71
phenotype
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.56   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 615   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.56   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 615   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (264)
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999958143
p_ni:  0.000041857
Data Source:  BioPlex
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.999950685
p_ni:  0.000049315
Data Source:  BioPlex
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.999884075
p_ni:  0.000115925
Data Source:  BioPlex
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
p_int:  0.999725945
p_ni:  0.000274055
Data Source:  BioPlex
ZNF318
Tbio
Novelty:  0.03072403
p_int:  0.999686777
p_ni:  0.000313214
p_wrong:  9e-9
Data Source:  BioPlex
ZNF644
Tbio
Family:  TF
Novelty:  0.12816167
p_int:  0.999602211
p_ni:  0.000397789
Data Source:  BioPlex
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.99901856
p_ni:  0.000981276
p_wrong:  1.65e-7
Data Source:  BioPlex
CELSR3
Tbio
Family:  GPCR
Novelty:  0.02705624
p_int:  0.997587919
p_ni:  0.00241208
Data Source:  BioPlex
ARHGAP22
Tbio
Family:  Enzyme
Novelty:  0.13037853
p_int:  0.997364599
p_ni:  0.002530687
p_wrong:  0.000104713
Data Source:  BioPlex
ZDBF2
Tdark
Novelty:  0.19205154
p_int:  0.996955833
p_ni:  0.003021254
p_wrong:  0.000022913
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homology Directed Repair
Reactome
Pre-NOTCH Expression and Processing
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homology Directed Repair
Pre-NOTCH Expression and Processing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-27 measurement
1
4
4
98.6
blood protein measurement
1
1
1
87.5
eosinophil count
2
2
2
67.1
lymphocyte count
2
2
2
64.2
triglyceride measurement
2
2
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-27 measurement
4
98.6
blood protein measurement
1
87.5
eosinophil count
2
67.1
lymphocyte count
2
64.2
triglyceride measurement
2
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sirtuin 6
VGNC:12101
737026
Macaque
sirtuin 6
714545
Mouse
MGI:1354161
50721
Rat
RGD:1305216
299638
Dog
sirtuin 6
VGNC:46187
485045
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sirtuin 6
Macaque
sirtuin 6
Mouse
Rat
Dog
sirtuin 6
Publication Statistics
PubMed Score 773.56
PubMed score by year
PubTator Score 207.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title