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Tchem
SIRT5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

Protein Summary
Description
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. This gene encodes a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359782
  • ENSP00000352830
  • ENSG00000124523
  • ENST00000379262
  • ENSP00000368564
  • ENST00000397350
  • ENSP00000380509
  • ENST00000606117
  • ENSP00000476228

Symbol
  • SIR2L5
  • SIR2L5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
molecular function
0.88
histone modification site profile
0.82
disease perturbation
0.79
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.63   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 581   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.63   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 581   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (44)
CHEMBL4091790
Rendered image for CHEMBL4091790
CHEMBL4064460
Rendered image for CHEMBL4064460
CHEMBL4068735
Rendered image for CHEMBL4068735
CHEMBL4092751
Rendered image for CHEMBL4092751
CHEMBL4065067
Rendered image for CHEMBL4065067
CHEMBL4100475
Rendered image for CHEMBL4100475
CHEMBL4073655
Rendered image for CHEMBL4073655
CHEMBL4091258
Rendered image for CHEMBL4091258
CHEMBL4100351
Rendered image for CHEMBL4100351
Protein-Protein Interactions (171)
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.999739648
p_ni:  0.000260346
p_wrong:  6e-9
Score:  0.249
Data Source:  BioPlex,STRINGDB
HBZ
Tbio
Novelty:  0.00331625
p_int:  0.999084113
p_ni:  0.000894879
p_wrong:  0.000021009
Score:  0.232
Data Source:  BioPlex,STRINGDB
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.998544299
p_ni:  0.001455699
p_wrong:  2e-9
Score:  0.178
Data Source:  BioPlex,STRINGDB
RABL3
Tbio
Family:  Enzyme
Novelty:  0.13941945
p_int:  0.998135305
p_ni:  0.001838706
p_wrong:  0.000025989
Score:  0.236
Data Source:  BioPlex,STRINGDB
THEM4
Tbio
Family:  Enzyme
Novelty:  0.0191855
p_int:  0.998135305
p_ni:  0.001838706
p_wrong:  0.000025989
Score:  0.173
Data Source:  BioPlex,STRINGDB
CPLX3
Tbio
Novelty:  0.07332857
p_int:  0.997508282
p_ni:  0.002225127
p_wrong:  0.000266591
Score:  0.179
Data Source:  BioPlex,STRINGDB
GYG2
Tbio
Family:  Enzyme
Novelty:  0.01520991
p_int:  0.995233294
p_ni:  0.004766704
p_wrong:  2e-9
Score:  0.17
Data Source:  BioPlex,STRINGDB
RBM5
Tbio
Novelty:  0.01706857
p_int:  0.994192554
p_ni:  0.005679367
p_wrong:  0.000128078
Data Source:  BioPlex
SEMA4A
Tbio
Novelty:  0.01062916
p_int:  0.993663319
p_ni:  0.006091591
p_wrong:  0.00024509
Data Source:  BioPlex
CWC15
Tbio
Novelty:  0.00205068
p_int:  0.980725255
p_ni:  0.015452009
p_wrong:  0.003822736
Score:  0.455
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Mitochondrial biogenesis (R-HSA-1592230)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
64.8
hemoglobin measurement
2
2
2
53.2
lymphocyte percentage of leukocytes
1
1
1
28.8
aspartate aminotransferase measurement
1
1
0
8.7
21.3
neutrophil percentage of leukocytes
1
1
1
15.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
64.8
hemoglobin measurement
2
53.2
lymphocyte percentage of leukocytes
1
28.8
aspartate aminotransferase measurement
0
8.7
21.3
neutrophil percentage of leukocytes
1
15.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sirtuin 5
VGNC:11282
747069
Macaque
sirtuin 5
700855
Mouse
MGI:1915596
68346
Rat
RGD:1303285
306840
Dog
sirtuin 5
VGNC:46186
478726
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sirtuin 5
Macaque
sirtuin 5
Mouse
Rat
Dog
sirtuin 5
Publication Statistics
PubMed Score 444.63
PubMed score by year
PubTator Score 95.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title