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Tchem
SIRT3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Protein Summary
Description
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). This gene encodes a member of the sirtuin family o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382743
  • ENSP00000372191
  • ENSG00000142082
  • ENST00000529382
  • ENSP00000437216

Symbol
  • SIR2L3
  • SIR2L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
virus perturbation
0.88
biological term
0.79
histone modification site profile
0.78
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1559.31   (req: < 5)
Gene RIFs: 181   (req: <= 3)
Antibodies: 711   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1559.31   (req: >= 5)
Gene RIFs: 181   (req: > 3)
Antibodies: 711   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0