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Tchem
SIRT1
NAD-dependent protein deacetylase sirtuin-1

Protein Summary
Description
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, Pu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000212015
  • ENSP00000212015
  • ENSG00000096717

Symbol
  • SIR2L1
  • SIR2
  • SIR2L1
  • SIR2alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
chemical
0.99
hub protein
0.92
gene perturbation
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6141.81   (req: < 5)
Gene RIFs: 974   (req: <= 3)
Antibodies: 1001   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6141.81   (req: >= 5)
Gene RIFs: 974   (req: > 3)
Antibodies: 1001   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 137
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 103
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (103)
CHEMBL4438193
Rendered image for CHEMBL4438193
SRT1720
Rendered image for SRT1720
CHEMBL2332041
Rendered image for CHEMBL2332041
splitomicin
Rendered image for splitomicin
CHEMBL2332039
Rendered image for CHEMBL2332039
CHEMBL2332037
Rendered image for CHEMBL2332037
CHEMBL2338810
Rendered image for CHEMBL2338810
CHEMBL2332043
Rendered image for CHEMBL2332043
CHEMBL2332042
Rendered image for CHEMBL2332042
CHEMBL2332040
Rendered image for CHEMBL2332040
Protein-Protein Interactions (702)
ZBTB38
Tbio
Family:  TF
Novelty:  0.05048192
p_int:  0.999994366
p_ni:  0.000005634
Score:  0.164
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999943713
p_ni:  0.000056287
Score:  0.262
Data Source:  BioPlex,STRINGDB
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.999934409
p_ni:  0.000065591
Score:  0.204
Data Source:  BioPlex,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.99991614
p_ni:  0.00008386
Score:  0.28
Data Source:  BioPlex,STRINGDB
CDKL1
Tchem
Family:  Kinase
Novelty:  0.110338
p_int:  0.998869104
p_ni:  0.001130896
Score:  0.447
Data Source:  BioPlex,STRINGDB
SFRP4
Tbio
Novelty:  0.00174428
p_int:  0.998859276
p_ni:  0.001140724
Score:  0.2
Data Source:  BioPlex,STRINGDB
ZNF514
Tdark
Family:  TF
Novelty:  8.86800961
p_int:  0.998747015
p_ni:  0.001252985
Data Source:  BioPlex
CERKL
Tbio
Family:  Enzyme
Novelty:  0.04190552
p_int:  0.998605785
p_ni:  0.001394215
Score:  0.161
Data Source:  BioPlex,STRINGDB
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  0.998450778
p_ni:  0.001549222
Score:  0.83
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.998272673
p_ni:  0.001727327
Score:  0.98
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (132)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Circadian Clock
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Circadian Clock
Epigenetic regulation of gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (151)
Find Similar Targets
Items per page:
10
1 – 10 of 23
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
73.4
mean platelet volume
2
2
2
64.8
leukocyte count
1
1
1
56.8
alkaline phosphatase measurement
1
1
1
45.7
sex hormone-binding globulin measurement
2
1
2
28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
73.4
mean platelet volume
2
64.8
leukocyte count
1
56.8
alkaline phosphatase measurement
1
45.7
sex hormone-binding globulin measurement
2
28
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sirtuin 1
VGNC:12502
107966703
Macaque
sirtuin 1
695682
Mouse
MGI:2135607
93759
Dog
sirtuin 1
VGNC:46183
489012
Horse
sirtuin 1
VGNC:51676
100072571
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sirtuin 1
Macaque
sirtuin 1
Mouse
Dog
sirtuin 1
Horse
sirtuin 1
Publication Statistics
PubMed Score 6141.81
PubMed score by year
PubTator Score 2618.06
PubTator score by year
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Related Publications
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PMID
Year
Title