Tbio SIRPA Tyrosine-protein phosphatase non-receptor type substrate 1

Protein Summary

Description

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78324
• A2A2E1
• A8K411
• B2R6C3
• O00683
• O43799
• Q8N517
• Q8TAL8
• Q9H0Z2
• Q9UDX2
• Q9UIJ6
• Q9Y4U9
• SHP substrate 1

Gene Name

• SIRPA

Ensembl ID

• ENST00000356025
• ENSP00000348307
• ENSG00000198053
• ENST00000358771
• ENSP00000351621
• ENST00000400068
• ENSP00000382941
• ENST00000622179
• ENSP00000478763

Symbol

• BIT
• MFR
• MYD1
• PTPNS1
• SHPS1
• SIRP
• BIT
• MFR
• P84
• SIRP
• MYD-1
• SHPS1
• CD172A
• PTPNS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.96
transcription factor perturbation	0.91
disease perturbation	0.9
virus perturbation	0.88
transcription factor	0.75

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / Tyrosine-protein Phosphatase Non-receptor Type Substrate 1

DTO Classes

Protein / Signaling / Chemokine / Tyrosine-protein Phosphatase Non-receptor Type Substrate 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.16   (req: < 5)

Gene RIFs: 100   (req: <= 3)

Antibodies: 784   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.16   (req: >= 5)

Gene RIFs: 100   (req: > 3)

Antibodies: 784   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0