Tdark SIPA1L1 Signal-induced proliferation-associated 1-like protein 1

Protein Summary

Description

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Uniprot Accession IDs

• O43166
• J3KP19
• O95321
• Q9UDU4
• Q9UNU4
• SIPA1-like protein 1

Gene Name

• SIPA1L1

Ensembl ID

• ENST00000358550
• ENSP00000351352
• ENSG00000197555
• ENST00000381232
• ENSP00000370630
• ENST00000555818
• ENSP00000450832

Symbol

• E6TP1
• KIAA0440
• E6TP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
drug perturbation	0.87
ligand (protein) perturbation	0.83
transcription factor perturbation	0.74
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Signal-induced Proliferation-associated 1-like Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Signal-induced Proliferation-associated 1-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.13   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.13   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0