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Tbio
SIPA1
Signal-induced proliferation-associated protein 1

Protein Summary
Description
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394224
  • ENSP00000377771
  • ENSG00000213445
  • ENST00000534313
  • ENSP00000436269

Symbol
  • SPA1
  • SPA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.83
transcription factor binding site profile
0.71
cellular component
0.69
histone modification site profile
0.68
interacting protein
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.62   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.62   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
SIPA1L3
Tbio
Novelty:  0.13962558
p_int:  0.999999953
p_ni:  4.6e-8
p_wrong:  1e-9
Data Source:  BioPlex
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.944
Data Source:  Reactome,STRINGDB
AFDN
Tbio
Novelty:  0.00372947
Score:  0.94
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.932
Data Source:  Reactome,STRINGDB
RRP1B
Tbio
Novelty:  0.08490415
Score:  0.828
Data Source:  STRINGDB
BRD4
Tchem
Family:  Epigenetic
Novelty:  0.0013933
Score:  0.661
Data Source:  STRINGDB
RAP2A
Tbio
Family:  Enzyme
Novelty:  0.00541101
Score:  0.639
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.638
Data Source:  STRINGDB
EXOC6B
Tbio
Novelty:  0.11301293
Score:  0.634
Data Source:  STRINGDB
MUS81
Tbio
Family:  Enzyme
Novelty:  0.00532122
Score:  0.597
Data Source:  STRINGDB
Nearest Tclin Targets (21)
Explore Nearest Tclin Targets
1 – 5 of 18
MET
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  1
PDGFRB
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  1
FGFR4
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  1
KDR
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  1
EPHA2
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  1
Pathways (181)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Rap1 signalling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Rap1 signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
5
97.8
heel bone mineral density
3
6
8
95.7
urate measurement
4
5
6
94.9
glomerular filtration rate
3
4
5
93.8
mean platelet volume
3
2
3
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
97.8
heel bone mineral density
8
95.7
urate measurement
6
94.9
glomerular filtration rate
5
93.8
mean platelet volume
3
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal-induced proliferation-associated 1
100613223
Macaque
signal-induced proliferation-associated 1
715958
Mouse
MGI:107576
20469
Rat
RGD:1303184
361710
Dog
signal-induced proliferation-associated 1
VGNC:46179
483730
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal-induced proliferation-associated 1
Macaque
signal-induced proliferation-associated 1
Mouse
Rat
Dog
signal-induced proliferation-associated 1
Publication Statistics
PubMed Score 30.62
PubMed score by year
PubTator Score 47.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title