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Tdark
SINHCAF
SIN3-HDAC complex-associated factor

Protein Summary
Description
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337682
  • ENSP00000337477
  • ENSG00000139146
  • ENST00000454658
  • ENSP00000393279
  • ENST00000539409
  • ENSP00000443697
  • ENST00000542983
  • ENSP00000439952
  • ENST00000617411
  • ENSP00000479093
  • ENSG00000276371
  • ENST00000631598
  • ENSP00000488852
  • ENST00000633702
  • ENSP00000488570
  • ENST00000633815
  • ENSP00000488406

Symbol
  • C12orf14
  • FAM60A
  • L4
  • TERA
  • FAM60A
  • C12orf14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0