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Tdark
SINHCAF
SIN3-HDAC complex-associated factor

Protein Summary
Description
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337682
  • ENSP00000337477
  • ENSG00000139146
  • ENST00000454658
  • ENSP00000393279
  • ENST00000539409
  • ENSP00000443697
  • ENST00000542983
  • ENSP00000439952
  • ENST00000617411
  • ENSP00000479093
  • ENSG00000276371
  • ENST00000631598
  • ENSP00000488852
  • ENST00000633702
  • ENSP00000488570
  • ENST00000633815
  • ENSP00000488406

Symbol
  • C12orf14
  • FAM60A
  • L4
  • TERA
  • FAM60A
  • C12orf14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  1
Score:  0.972
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  1
Score:  0.958
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  1
Score:  0.941
Data Source:  BioPlex,STRINGDB
SAP130
Tdark
Family:  Enzyme
Novelty:  1.85084032
p_int:  0.999999987
p_ni:  1.1e-8
p_wrong:  1e-9
Score:  0.838
Data Source:  BioPlex,STRINGDB
ARID4A
Tbio
Family:  TF; Epigenetic
Novelty:  0.04953333
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.777
Data Source:  BioPlex,STRINGDB
ARID4B
Tbio
Family:  TF; Epigenetic
Novelty:  0.04182223
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.457
Data Source:  BioPlex,STRINGDB
SUDS3
Tbio
Family:  Enzyme
Novelty:  0.03837881
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.913
Data Source:  BioPlex,STRINGDB
BRMS1
Tbio
Novelty:  0.01689792
p_int:  0.999999955
p_ni:  4.4e-8
p_wrong:  1e-9
Score:  0.773
Data Source:  BioPlex,STRINGDB
SAP30
Tbio
Family:  Enzyme
Novelty:  0.03474176
p_int:  0.999999935
p_ni:  6.5e-8
Score:  0.967
Data Source:  BioPlex,STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
p_int:  0.99999991
p_ni:  8.7e-8
p_wrong:  3e-9
Score:  0.965
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
3
1.1
93.1
body mass index
1
1
1
50.6
self reported educational attainment
2
2
2
48.3
HbA1c measurement
1
1
1
36.9
glomerular filtration rate
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
93.1
body mass index
1
50.6
self reported educational attainment
2
48.3
HbA1c measurement
1
36.9
glomerular filtration rate
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SIN3-HDAC complex associated factor
694162
Mouse
MGI:1929091
56306
Rat
RGD:1595037
686611
Dog
SIN3-HDAC complex associated factor
VGNC:49879
477652
Horse
SIN3-HDAC complex associated factor
VGNC:22984
100069812
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SIN3-HDAC complex associated factor
Mouse
Rat
Dog
SIN3-HDAC complex associated factor
Horse
SIN3-HDAC complex associated factor
Publication Statistics
PubMed Score 9.02
PubMed score by year
PubTator Score 6.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title