SIN3B
Paired amphipathic helix protein Sin3b
Protein Summary
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
- ENST00000248054
- ENSP00000248054
- ENSG00000127511
- ENST00000379803
- ENSP00000369131
- ENST00000596802
- ENSP00000473039
- KIAA0700
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.98 | ||
disease perturbation | 0.97 | ||
transcription factor perturbation | 0.97 | ||
biological process | 0.7 | ||
molecular function | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.24 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 216 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.24 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 216 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0