Tbio SIN3A Paired amphipathic helix protein Sin3a

Protein Summary

Description

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96ST3
• B2RNS5
• Q8N8N4
• Q8NC83
• Q8WV18
• Q96L98
• Q9UFQ1

Gene Name

• SIN3A

Ensembl ID

• ENST00000360439
• ENSP00000353622
• ENSG00000169375
• ENST00000394947
• ENSP00000378402
• ENST00000394949
• ENSP00000378403

Symbol

• WITKOS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
molecular function	0.99
drug perturbation	0.96
interacting protein	0.91

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Paired Amphipathic Helix Protein Sin3a

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Paired Amphipathic Helix Protein Sin3a

Protein / Hydrolase / Deacetylase / Paired Amphipathic Helix Protein Sin3a

DTO Classes

Protein / Enzyme / Hydrolase / Deacetylase / Paired Amphipathic Helix Protein Sin3a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.59   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.59   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0