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Tbio
SIL1
Nucleotide exchange factor SIL1

Protein Summary
Description
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265195
  • ENSP00000265195
  • ENSG00000120725
  • ENST00000394817
  • ENSP00000378294

Symbol
  • BAP
  • MSS
  • ULG5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
kinase perturbation
0.81
transcription factor binding site profile
0.76
tissue
0.72
transcription factor
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.69   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.69   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (329)
CEP192
Tbio
Novelty:  0.05738998
p_int:  0.999999867
p_ni:  1.32e-7
p_wrong:  2e-9
Data Source:  BioPlex
POC1A
Tbio
Novelty:  0.03897985
p_int:  0.999997144
p_ni:  0.000002856
Data Source:  BioPlex
POC1B
Tbio
Novelty:  0.09023863
p_int:  0.999203958
p_ni:  0.000670451
p_wrong:  0.000125591
Score:  0.181
Data Source:  BioPlex,STRINGDB
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.997982466
p_ni:  0.002017534
Data Source:  BioPlex
CNTNAP1
Tbio
Novelty:  0.00618741
p_int:  0.996496329
p_ni:  0.003499349
p_wrong:  0.000004322
Data Source:  BioPlex
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.981618403
p_ni:  0.018381597
Data Source:  BioPlex
ERGIC2
Tbio
Novelty:  0.08610944
p_int:  0.959209272
p_ni:  0.040733097
p_wrong:  0.000057631
Score:  0.161
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.935648905
p_ni:  0.064351095
Score:  0.886
Data Source:  BioPlex,STRINGDB
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.928587142
p_ni:  0.071412858
Score:  0.513
Data Source:  BioPlex,STRINGDB
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.915845228
p_ni:  0.084154772
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
1
1
86.9
risk-taking behaviour
1
1
1
52.4
reticulocyte count
1
1
1
49.5
reticulocyte measurement
2
1
2
45.2
biological sex
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
86.9
risk-taking behaviour
1
52.4
reticulocyte count
1
49.5
reticulocyte measurement
2
45.2
biological sex
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SIL1 nucleotide exchange factor
VGNC:4164
747459
Macaque
SIL1 nucleotide exchange factor
714762
Mouse
MGI:1932040
81500
Rat
RGD:735103
291673
Dog
SIL1 nucleotide exchange factor
VGNC:46173
474699
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SIL1 nucleotide exchange factor
Macaque
SIL1 nucleotide exchange factor
Mouse
Rat
Dog
SIL1 nucleotide exchange factor
Publication Statistics
PubMed Score 119.69
PubMed score by year
PubTator Score 67.71
PubTator score by year
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Related Publications
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PMID
Year
Title