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Tbio
SIKE1
Suppressor of IKBKE 1

Protein Summary
Description
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000060969
  • ENSP00000060969
  • ENSG00000052723
  • ENST00000369528
  • ENSP00000358541

Symbol
  • SIKE
  • SIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor perturbation
0.8
transcription factor binding site profile
0.73
cell type or tissue
0.72
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
TRAF3IP3
Tbio
Novelty:  0.12180834
p_int:  0.999999991
p_ni:  9e-9
Score:  0.86
Data Source:  BioPlex,STRINGDB
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.999999976
p_ni:  2.3e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
STRN
Tbio
Novelty:  0.01025814
p_int:  0.999999954
p_ni:  4.7e-8
Score:  0.941
Data Source:  BioPlex,STRINGDB
STRN3
Tbio
Novelty:  0.10331283
p_int:  0.999997603
p_ni:  0.000002396
p_wrong:  2e-9
Score:  0.918
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999956696
p_ni:  0.000043303
Score:  0.338
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999621631
p_ni:  0.000378369
Score:  0.877
Data Source:  BioPlex,STRINGDB
STRIP2
Tbio
Novelty:  0.19321125
p_int:  0.999195975
p_ni:  0.000803896
p_wrong:  1.29e-7
Score:  0.954
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.998913694
p_ni:  0.001086306
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.998163808
p_ni:  0.001836181
p_wrong:  1.1e-8
Data Source:  BioPlex
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.997964612
p_ni:  0.002032979
p_wrong:  0.000002409
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (121)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
TRAF3-dependent IRF activation pathway
Reactome
TRAF6 mediated IRF7 activation
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
37.6
comparative body size at age 10, self-reported
1
1
1
21.5
age at first sexual intercourse measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
37.6
comparative body size at age 10, self-reported
1
21.5
age at first sexual intercourse measurement
1
2.9
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
suppressor of IKBKE 1
VGNC:1548
457146
Macaque
suppressor of IKBKE 1
708999
Mouse
MGI:1913891
66641
Rat
RGD:1311316
362007
Dog
suppressor of IKBKE 1
VGNC:46172
483131
Species
Name
OMA
EggNOG
Inparanoid
Chimp
suppressor of IKBKE 1
Macaque
suppressor of IKBKE 1
Mouse
Rat
Dog
suppressor of IKBKE 1
Publication Statistics
PubMed Score 9.01
PubMed score by year
PubTator Score 3.99
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title