SIK2
Serine/threonine-protein kinase SIK2
Protein Summary
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
- ENST00000304987
- ENSP00000305976
- ENSG00000170145
- KIAA0781
- QIK
- SNF1LK2
- QIK
- SIK-2
- SNF1LK2
- LOH11CR1I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
molecular function | 0.95 | ||
protein domain | 0.92 | ||
virus perturbation | 0.92 | ||
interacting protein | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.52 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 280 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.52 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 280 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 26
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2