SIK2
Serine/threonine-protein kinase SIK2
Protein Summary
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
- ENST00000304987
- ENSP00000305976
- ENSG00000170145
- KIAA0781
- QIK
- SNF1LK2
- QIK
- SIK-2
- SNF1LK2
- LOH11CR1I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
molecular function | 0.95 | ||
protein domain | 0.92 | ||
virus perturbation | 0.92 | ||
interacting protein | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.33 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 280 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.33 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 280 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 21
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (21)
Protein-Protein Interactions (41)
PPP2R2C
Family: Enzyme
Novelty: 0.05453128
p_int: 0.999963282
p_ni: 0.000036716
p_wrong: 2e-9
Score: 0.656
Data Source: BioPlex,STRINGDB
SIK1
Family: Kinase
Novelty: 0.00523549
p_int: 0.999914533
p_ni: 0.000080763
p_wrong: 0.000004704
Score: 0.388
Data Source: BioPlex,STRINGDB
IL17RA
Novelty: 0.00416706
p_int: 0.999075653
p_ni: 0.000924321
p_wrong: 2.6e-8
Data Source: BioPlex
PROZ
Family: Enzyme
Novelty: 0.05629679
p_int: 0.993832175
p_ni: 0.005384717
p_wrong: 0.000783107
Score: 0.183
Data Source: BioPlex,STRINGDB
TULP2
Family: TF
Novelty: 0.20144336
p_int: 0.986704071
p_ni: 0.012925832
p_wrong: 0.000370097
Score: 0.177
Data Source: BioPlex,STRINGDB
IL13RA2
Novelty: 0.03465642
p_int: 0.947245345
p_ni: 0.026209228
p_wrong: 0.026545427
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
KEGG (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Glucagon signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glucagon signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 4 | 5 | 6 | 95.6 | |||||
waist-hip ratio | 2 | 5 | 5 | 93.4 | |||||
BMI-adjusted waist circumference | 1 | 6 | 6 | 92.6 | |||||
waist circumference | 1 | 4 | 4 | 91 | |||||
6 | 5 | 0 | 1 | 88.2 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 6 | 95.6 | |||||
waist-hip ratio | 5 | 93.4 | |||||
BMI-adjusted waist circumference | 6 | 92.6 | |||||
waist circumference | 4 | 91 | |||||
0 | 1 | 88.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | salt inducible kinase 2 | VGNC:3236 | 451540 | |||||
Macaque | salt inducible kinase 2 [Source:HGNC Symbol;Acc:HGNC:21680] | |||||||
Mouse | MGI:2445031 | 235344 | ||||||
Rat | RGD:1559698 | 315649 | ||||||
Dog | salt inducible kinase 2 | VGNC:53440 | 489410 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | salt inducible kinase 2 | |||||
Macaque | salt inducible kinase 2 [Source:HGNC Symbol;Acc:HGNC:21680] | |||||
Mouse | ||||||
Rat | ||||||
Dog | salt inducible kinase 2 | |||||
Publication Statistics
PubMed Score 73.33
PubMed score by year
PubTator Score 21.11
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (38)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
|---|