You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SIGLEC9
Sialic acid-binding Ig-like lectin 9

Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250360
  • ENSP00000250360
  • ENSG00000129450
  • ENST00000440804
  • ENSP00000413861

Symbol
  • CD329
  • CDw329
  • FOAP-9
  • siglec-9
  • OBBP-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.76
cell type or tissue
0.63
protein domain
0.58
gene perturbation
0.53
tissue
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.41   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.41   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
NCAM1
Tbio
Novelty:  0.00020994
p_int:  0.99949104
p_ni:  0.00050896
Score:  0.623
Data Source:  BioPlex,STRINGDB
KLK14
Tchem
Family:  Enzyme
Novelty:  0.02007434
Score:  0.8
Data Source:  STRINGDB
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
Score:  0.781
Data Source:  STRINGDB
KLK13
Tchem
Family:  Enzyme
Novelty:  0.01963129
Score:  0.715
Data Source:  STRINGDB
TLR8
Tchem
Novelty:  0.0023384
Score:  0.652
Data Source:  STRINGDB
TLR2
Tchem
Novelty:  0.00023242
Score:  0.605
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.599
Data Source:  STRINGDB
CD300LF
Tbio
Novelty:  0.01373075
Score:  0.574
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.566
Data Source:  STRINGDB
SIGLEC7
Tchem
Novelty:  0.01496432
Score:  0.556
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
85.4
leukocyte count
2
2
2
84.4
myeloid white cell count
1
1
1
83.1
platelet crit
2
2
2
82.7
C-reactive protein measurement
1
2
2
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
85.4
leukocyte count
2
84.4
myeloid white cell count
1
83.1
platelet crit
2
82.7
C-reactive protein measurement
2
74.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 64.41
PubMed score by year
PubTator Score 46.66
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title